Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA004166-10
Application #
2117041
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1986-08-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Pharmacy
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Wang, Danxin; Sun, Xiaochun; Sadee, Wolfgang (2007) Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment. J Pharmacol Exp Ther 321:544-52
Lucas, Julie L; Wang, Danxin; Sadee, Wolfgang (2006) Calmodulin binding to peptides derived from the i3 loop of muscarinic receptors. Pharm Res 23:647-53
Zhang, Ying; Wang, Danxin; Sadee, Wolfgang (2005) Calmodulin interaction with peptides from G-protein coupled receptors measured with S-Tag labeling. Biochem Biophys Res Commun 333:390-5
Sadee, Wolfgang; Wang, Danxin; Bilsky, Edward J (2005) Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities. Life Sci 76:1427-37
Wang, Danxin; Sun, Xiaochun; Bohn, Laura M et al. (2005) Opioid receptor homo- and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer. Mol Pharmacol 67:2173-84
Raehal, Kirsten M; Lowery, John J; Bhamidipati, Castigliano M et al. (2005) In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice. J Pharmacol Exp Ther 313:1150-62
Wang, Danxin; Raehal, Kirsten M; Lin, Emil T et al. (2004) Basal signaling activity of mu opioid receptor in mouse brain: role in narcotic dependence. J Pharmacol Exp Ther 308:512-20
Quillan, J Mark; Carlson, Kurt W; Song, Chunyan et al. (2002) Differential effects of mu-opioid receptor ligands on Ca(2+) signaling. J Pharmacol Exp Ther 302:1002-12
Lin, Kedan; Wang, Danxin; Sadee, Wolfgang (2002) Serum response factor activation by muscarinic receptors via RhoA. Novel pathway specific to M1 subtype involving calmodulin, calcineurin, and Pyk2. J Biol Chem 277:40789-98
Wang, D; Raehal, K M; Bilsky, E J et al. (2001) Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence. J Neurochem 77:1590-600

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