Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA004265-10
Application #
2117101
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1987-01-01
Project End
1997-07-31
Budget Start
1996-01-01
Budget End
1997-07-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Pharmacology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Reid, M J; Bornheim, L M (2001) Cannabinoid-induced alterations in brain disposition of drugs of abuse. Biochem Pharmacol 61:1357-67
Reid, M J; Bornheim, L M (2001) The effects of phencyclidine pretreatment on cocaine-mediated hepatotoxicity in mice. Toxicol Appl Pharmacol 172:194-202
Bornheim, L M (2000) Effects of unsaturated side-chain analogs of tetrahydrocannabinol on cytochromes P450. Biochem Pharmacol 60:955-61
Jager, W; Correia, M A; Bornheim, L M et al. (1999) Ethynylestradiol-mediated induction of hepatic CYP3A9 in female rats: implication for cyclosporine metabolism. Drug Metab Dispos 27:1505-11
He, K; Bornheim, L M; Falick, A M et al. (1998) Identification of the heme-modified peptides from cumene hydroperoxide-inactivated cytochrome P450 3A4. Biochemistry 37:17448-57
Bornheim, L M (1998) Effect of cytochrome P450 inducers on cocaine-mediated hepatotoxicity. Toxicol Appl Pharmacol 150:158-65
Bornheim, L M; Grillo, M P (1998) Characterization of cytochrome P450 3A inactivation by cannabidiol: possible involvement of cannabidiol-hydroxyquinone as a P450 inactivator. Chem Res Toxicol 11:1209-16
Kim, K Y; Bornheim, L M (1997) Determination of esterase-catalyzed cocaine metabolite formation by high-performance liquid chromatography with ultraviolet detection. J Chromatogr Sci 35:287-90
Jaeger, W; Benet, L Z; Bornheim, L M (1996) Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes. Xenobiotica 26:275-84
Hampson, A J; Hill, W A; Zan-Phillips, M et al. (1995) Anandamide hydroxylation by brain lipoxygenase:metabolite structures and potencies at the cannabinoid receptor. Biochim Biophys Acta 1259:173-9

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