The overall objective of this study is to determine the impact of in utero cocaine exposure upon perinatal outcome and neurodevelopmental consequences in the infant. The study and control groups will be drawn from an inial survey population of 2,250 North American black women delivering at the University of Miami/Jackson Memorial Hospital (UM/)JMH). A detailed substance abuse history, maternal and infant urine toxicology assays, and serologic testing for human immunodeficiency virus (HIV-1) will be performed at delivery. The association between maternal cocaine use and adverse perinatal outcome, including prematurity, intrauterine growth retardation, abruptio placenta, and fetal demise will be assessed. A prospective longitudinal study will be performed to assess neurobehavioral status, neurodevelopmental outcome and auditory function, of 250 cocaine- exposed term infants compared to two groups of control term infants. The first control group (n=125) will include infants unexposed to cocaine but exposed to alcohol and/or marijuana. The second control group (n=125) will be drug-free, i.e. unexposed to cocaine, alcohol, or marijuana. Physical and neurologic examinations will be performed during the delivery hospitalization and at 1,6,12,18, and 24 months and yearly thereafter. The Motor Assessment Inventory will be performed at 4 months. Bayley Scales of Infant Development will be administered at 6,12,18, and 24 months. Stanford-Binet will be utilized at 3 and 4 years. Auditory brainstem evoked response (ABR) will be performed at birth with repeat ABR at 1 month if abnormal. Behavioral audiology assessments will be performed at 1 and 3 years. Echoencephalographic studies will be obtained during the first postnatal week and at 1 and 6 months postnatal month and at 9 and 21 months postnatal week and at 1 and 6 months postnatal age. Cranial magnetic resonance imaging (MRI) will be performed in the first postnatal month and at 9 and 21 months postnatal age to complement echoencephalography in detecting parenchymal abnormalities and to delineate myelination patterns in all infants with abnormal echoencephalograms and in 40 randomly selected infants without abnormal echoencephalographic findings (20 in the cocaine- exposed group and 10 in each control group). Serial ABR will also be performed at 1,4,9, and 21 months in all infants undergoing serial MRI studies. Future efforts at developing strategies to combat perinatal cocaine use and minimize its impact upon exposed infants should be enhanced by the project.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA006556-05
Application #
2118764
Study Section
Special Emphasis Panel (SRCD (32))
Project Start
1990-04-01
Project End
1995-03-31
Budget Start
1994-04-01
Budget End
1995-03-31
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Miami School of Medicine
Department
Pediatrics
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146
Messiah, Sarah E; Ludwig, David A; Vidot, Denise C et al. (2015) Prenatal Cocaine Exposure and Cardiometabolic Disease Risk Factors in 18- to 20-Year-Old African Americans. Ethn Dis 25:419-26
Mansoor, Elana; Morrow, Connie E; Accornero, Veronica H et al. (2012) Longitudinal effects of prenatal cocaine use on mother-child interactions at ages 3 and 5 years. J Dev Behav Pediatr 33:32-41
Bandstra, Emmalee S; Morrow, Connie E; Accornero, Veronica H et al. (2011) Estimated effects of in utero cocaine exposure on language development through early adolescence. Neurotoxicol Teratol 33:25-35
Accornero, Veronica H; Anthony, James C; Morrow, Connie E et al. (2011) Estimated effect of prenatal cocaine exposure on examiner-rated behavior at age 7 years. Neurotoxicol Teratol 33:370-8
Bandstra, Emmalee S; Morrow, Connie E; Mansoor, Elana et al. (2010) Prenatal drug exposure: infant and toddler outcomes. J Addict Dis 29:245-58
Morrow, Connie E; Xue, Lihua; Manjunath, Sudha et al. (2009) Estimated Risk of Developing Selected DSM-IV Disorders Among 5-Year-Old Children with Prenatal Cocaine Exposure. J Child Fam Stud 18:356-364
Accornero, Veronica H; Amado, Alfred J; Morrow, Connie E et al. (2007) Impact of prenatal cocaine exposure on attention and response inhibition as assessed by continuous performance tests. J Dev Behav Pediatr 28:195-205
Morrow, Connie E; Culbertson, Jan L; Accornero, Veronica H et al. (2006) Learning disabilities and intellectual functioning in school-aged children with prenatal cocaine exposure. Dev Neuropsychol 30:905-31
Accornero, Veronica H; Anthony, James C; Morrow, Connie E et al. (2006) Prenatal cocaine exposure: an examination of childhood externalizing and internalizing behavior problems at age 7 years. Epidemiol Psichiatr Soc 15:20-9
Morrow, Connie E; Vogel, April L; Anthony, James C et al. (2004) Expressive and receptive language functioning in preschool children with prenatal cocaine exposure. J Pediatr Psychol 29:543-54

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