The proposed revised application would continue research on a sample of 999 multiethnic adults who were longitudinally assessed from ages 11-12 to 23-24. Assessment included a CIDI diagnostic interview at age 18-19 and coded videotaped observations of adolescent family and peer interactions. The sample was individually randomized to the Family Check-Up model in adolescence, which yielded long-term effects on drug use, antisocial behavior, depression, and academic success. The proposed follow-up assessment at age 26- 27 would include the CIDI diagnostic interview on addictive behavior and psychopathology, time allocation to high- versus low-investment activities, peer network, self-regulation, and the collection of DNA in saliva samples. Three approaches to genotyping are proposed, including candidate gene, gene family, and novel gene exploration by a team of investigators currently studying the molecular genetics of addictive behavior. These data will be used to address the following hypotheses: (a) the disrupted self-regulation hypothesis, that adult problem behavior generally and addictive behavior specifically are part of an overall pattern of adaptation that is characterized by a low-investment strategy in respect to family relationships and other adult milestones, with low demands on self-regulation;(b) the genetic moderation hypothesis, indicating that the effects of poor parental monitoring and deviant peer exposure on progressions in AOD use and other problem behaviors are most pronounced for youth who are genetically vulnerable;and (c) the risk malleability hypothesis, which proposes that early environmental risk can be modified and that these effects are especially pronounced for genetically prone youth. Testing of all 3 sets of hypotheses requires examination of longitudinal data from early adolescence through age 26-27 that uses a variety of advanced analytic strategies, including trajectory analyses, latent profile analysis, latent growth modeling, and complier average causal effect modeling for examining the effects of the Family Check-Up on risk exposure.

Public Health Relevance

This application proposes a follow-up assessment at age 26-27 of 999 multiethnic, urban youth who had been involved in a longitudinal randomized controlled prevention trial of a family-centered intervention beginning at age 11, which will include strong measurement of the parenting and peer environment and genetic vulnerability. The study proposes to consider the joint role of genetic and environmental factors on the progression of adult AOD use, antisocial and high-risk sexual behavior, and the response of identified risk processes to family intervention. The research will lead to a better understanding of the risk and protective mechanisms, malleability of those mechanisms, and the design of more precise and innovative strategies for prevention and treatment of adult AOD and other problem behaviors.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
7R01DA007031-24
Application #
8779841
Study Section
Risk, Prevention and Intervention for Addictions Study Section (RPIA)
Program Officer
Crump, Aria
Project Start
1991-01-01
Project End
2016-05-31
Budget Start
2013-09-01
Budget End
2014-05-31
Support Year
24
Fiscal Year
2013
Total Cost
$600,698
Indirect Cost
$110,057
Name
Arizona State University-Tempe Campus
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
943360412
City
Tempe
State
AZ
Country
United States
Zip Code
85287
DeLay, Dawn; Ha, Thao; Van Ryzin, Mark et al. (2016) Changing Friend Selection in Middle School: A Social Network Analysis of a Randomized Intervention Study Designed to Prevent Adolescent Problem Behavior. Prev Sci 17:285-94
Connell, Arin M; McKillop, Hannah N; Dishion, Thomas J (2016) Long-Term Effects of the Family Check-Up in Early Adolescence on Risk of Suicide in Early Adulthood. Suicide Life Threat Behav 46 Suppl 1:S15-22
Véronneau, Marie-Hélène; Dishion, Thomas J; Connell, Arin M et al. (2016) A randomized, controlled trial of the family check-up model in public secondary schools: Examining links between parent engagement and substance use progressions from early adolescence to adulthood. J Consult Clin Psychol 84:526-43
Chiapa, Amanda; Parra Morris, Georgina; Véronneau, Marie Hélène et al. (2016) Translational research on parenting of adolescents: Linking theory to valid observation measures for family centered prevention and treatment. Transl Behav Med 6:90-104
Dick, Danielle M; Adkins, Amy E; Kuo, Sally I-Chun (2016) Genetic influences on adolescent behavior. Neurosci Biobehav Rev 70:198-205
Brown, C Hendricks; Brincks, Ahnalee; Huang, Shi et al. (2016) Two-Year Impact of Prevention Programs on Adolescent Depression: an Integrative Data Analysis Approach. Prev Sci :
Martin, Christina Gamache; Van Ryzin, Mark J; Dishion, Thomas J (2016) Profiles of childhood trauma: Betrayal, frequency, and psychological distress in late adolescence. Psychol Trauma 8:206-13
Salvatore, Jessica E; Dick, Danielle M (2016) Genetic influences on conduct disorder. Neurosci Biobehav Rev :
Marshall-Denton, Rhea; Véronneau, Marie-Hélène; Dishion, Thomas J (2016) Brief report: A confirmatory approach to the validation of the peer group norm questionnaire. J Adolesc 50:16-21
Connell, Arin M; Stormshak, Elizabeth; Dishion, Thomas et al. (2015) The Family Check Up and Adolescent Depression: An Examination of Treatment Responders and Non-Responders. Prev Sci :

Showing the most recent 10 out of 53 publications