Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
1R01DA009601-01A2
Application #
2122935
Study Section
Human Development Research Subcommittee (NIDA)
Project Start
1996-09-01
Project End
1999-07-31
Budget Start
1996-09-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Neurology
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Van Laar, Victor S; Mishizen, Amanda J; Cascio, Michael et al. (2009) Proteomic identification of dopamine-conjugated proteins from isolated rat brain mitochondria and SH-SY5Y cells. Neurobiol Dis 34:487-500
Dukes, April A; Van Laar, Victor S; Cascio, Michael et al. (2008) Changes in endoplasmic reticulum stress proteins and aldolase A in cells exposed to dopamine. J Neurochem 106:333-46
Van Laar, Victor S; Dukes, April A; Cascio, Michael et al. (2008) Proteomic analysis of rat brain mitochondria following exposure to dopamine quinone: implications for Parkinson disease. Neurobiol Dis 29:477-89
Dukes, April A; Korwek, Kimberly M; Hastings, Teresa G (2005) The effect of endogenous dopamine in rotenone-induced toxicity in PC12 cells. Antioxid Redox Signal 7:630-8
LaVoie, Matthew J; Card, J Patrick; Hastings, Teresa G (2004) Microglial activation precedes dopamine terminal pathology in methamphetamine-induced neurotoxicity. Exp Neurol 187:47-57
Perez, Ruth G; Hastings, Teresa G (2004) Could a loss of alpha-synuclein function put dopaminergic neurons at risk? J Neurochem 89:1318-24
Zigmond, Michael J; Hastings, Teresa G; Perez, Ruth G (2002) Increased dopamine turnover after partial loss of dopaminergic neurons: compensation or toxicity? Parkinsonism Relat Disord 8:389-93
Berman, S B; Watkins, S C; Hastings, T G (2000) Quantitative biochemical and ultrastructural comparison of mitochondrial permeability transition in isolated brain and liver mitochondria: evidence for reduced sensitivity of brain mitochondria. Exp Neurol 164:415-25
Stokes, A H; Hastings, T G; Vrana, K E (1999) Cytotoxic and genotoxic potential of dopamine. J Neurosci Res 55:659-65
LaVoie, M J; Hastings, T G (1999) Dopamine quinone formation and protein modification associated with the striatal neurotoxicity of methamphetamine: evidence against a role for extracellular dopamine. J Neurosci 19:1484-91

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