Substance misuse is the leading preventable cause of morbidity and mortality in females. Effective prevention of substance misuse by females, depends, in part on increased understanding of femalespecific risk and protective factors that influence pathways toward and away from addiction. The main goal of the proposed research, which directly addresses NIDA strategic priorities in ?prevention?, is to investigate factors influencing the development of substance use, abuse, and dependence in girls during a period of peak risk (ages 15-22). This renewal requests continuation of NIDA support for 5 further annual substance use assessments (i.e., Years 11-15) with girls and their parent as a substudy to the NIMH-funded Pittsburgh Girls Study (PGS;N = 2,451;52% African American, 41% Caucasian), a longitudinal, population-based study of the development of conduct problems and depression in four cohorts of girls, initially assessed at ages 5 to 8. The next 5 years, which will cover ages 15-22 in an accelerated longitudinal design, are critical to understanding factors influencing the development of substance use and HIV risk behaviors (e.g., risky sexual behavior) during adolescence and the transition to young adulthood. The proposed project aims to: (1) characterize trajectories of substance use, abuse, and dependence in girls, starting in childhood, through adolescence, and into emerging adulthood;(2) examine trajectories of girls? substance involvement in conjunction with the developmental course of psychopathology (e.g., depression) and other problem behaviors (e.g., risky sexual behavior);(3) determine how proximal and distal risk and protective factors (both general and female-specific) influence the development of substance involvement in girls, including analyses of differences by ethnicity;and (4) to simultaneously examine trajectories of substance use and HIV risk behaviors to determine how these health compromising behaviors interact over time to influence HIV risk in females. The proposed continuation of 5 annual substance use assessments, in conjunction with 10 waves of data already collected, will permit the linkage of childhood factors to substance use and HIV risk behaviors during adolescence and emerging adulthood. The PGS, as one of very few population-based studies of females in the US, is uniquely suited to addressing gaps in knowledge regarding the ways in which individual, environmental, and developmental factors interact to influence substance use in a large, urban sample of African American and Caucasian girls. Study findings will be used to improve substance use and HIV risk screening, and to guide prevention efforts for females.
Effective prevention of substance misuse and HIV risk behaviors (e.g., risky sexual behavior) by females, depends, in part, on increased understanding of female-specific risk and protective factors that influence the progression of substance use and HIV risk behaviors. This renewal application for the Pittsburgh Girls Study, a large community sample (n=2,451) of Caucasian and African American girls, will provide for 5 further annual substance use assessments, covering ages 15-22, a period of peak risk for the development of substance use and HIV risk behaviors in girls. Continued collection of substance use and HIV risk behavior data, in combination with 10 prior waves of substance use data collected since childhood, will provide important, new information that is critical to guiding the development of effective substance use and HIV risk behavior screening and prevention efforts for females.
|Stepp, Stephanie D; Scott, Lori N; Jones, Neil P et al. (2016) Negative emotional reactivity as a marker of vulnerability in the development of borderline personality disorder symptoms. Dev Psychopathol 28:213-24|
|Goldschmidt, Andrea B; Lavender, Jason M; Hipwell, Alison E et al. (2016) Emotion Regulation and Loss of Control Eating in Community-Based Adolescents. J Abnorm Child Psychol :|
|Wright, Aidan G C; Zalewski, Maureen; Hallquist, Michael N et al. (2016) Developmental Trajectories of Borderline Personality Disorder Symptoms and Psychosocial Functioning in Adolescence. J Pers Disord 30:351-72|
|Dermody, Sarah S; Marshal, Michael P; Cheong, JeeWon et al. (2016) Adolescent Sexual Minority Girls Are at Elevated Risk for Use of Multiple Substances. Subst Use Misuse 51:574-85|
|van der Molen, Elsa; Blokland, Arjan A J; Hipwell, Alison E et al. (2015) Girls' childhood trajectories of disruptive behavior predict adjustment problems in early adolescence. J Child Psychol Psychiatry 56:766-73|
|Goldschmidt, Andrea B; Hipwell, Alison E; Stepp, Stephanie D et al. (2015) Weight Gain, Executive Functioning, and Eating Behaviors Among Girls. Pediatrics 136:e856-63|
|Romens, Sarah E; Casement, Melynda D; McAloon, Rose et al. (2015) Adolescent girls' neural response to reward mediates the relation between childhood financial disadvantage and depression. J Child Psychol Psychiatry 56:1177-84|
|Scott, Lori N; Stepp, Stephanie D; Hallquist, Michael N et al. (2015) Daily shame and hostile irritability in adolescent girls with borderline personality disorder symptoms. Personal Disord 6:53-63|
|Scott, Lori N; Pilkonis, Paul A; Hipwell, Alison E et al. (2015) Non-suicidal self-injury and suicidal ideation as predictors of suicide attempts in adolescent girls: a multi-wave prospective study. Compr Psychiatry 58:1-10|
|Pardini, Dustin; White, Helene R; Xiong, Shuangyan et al. (2015) Unfazed or Dazed and Confused: Does Early Adolescent Marijuana Use Cause Sustained Impairments in Attention and Academic Functioning? J Abnorm Child Psychol 43:1203-17|
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