Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
3R01DA016715-04S1
Application #
7489661
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Park, Moo Kwang
Project Start
2004-04-15
Project End
2008-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
4
Fiscal Year
2007
Total Cost
$32,893
Indirect Cost

  Institution

Name
University of Maryland Baltimore
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201

  Publications

Mason, Clifford W; Hassan, Hazem E; Kim, Kang-Pil et al. (2010) Characterization of the transport, metabolism, and pharmacokinetics of the dopamine D3 receptor-selective fluorenyl- and 2-pyridylphenyl amides developed for treatment of psychostimulant abuse. J Pharmacol Exp Ther 333:854-64
Tolson, Antonia H; Li, Haishan; Eddington, Natalie D et al. (2009) Methadone induces the expression of hepatic drug-metabolizing enzymes through the activation of pregnane X receptor and constitutive androstane receptor. Drug Metab Dispos 37:1887-94
Othman, Ahmed A; Newman, Amy H; Eddington, Natalie D (2008) The novel N-substituted benztropine analog GA2-50 possesses pharmacokinetic and pharmacodynamic profiles favorable for a candidate substitute medication for cocaine abuse. J Pharm Sci 97:5453-70
Syed, Shariq A; Newman, Amy H; Othman, Ahmed A et al. (2008) Population pharmacokinetics, brain distribution, and pharmacodynamics of 2nd generation dopamine transporter selective benztropine analogs developed as potential substitute therapeutics for treatment of cocaine abuse. J Pharm Sci 97:1993-2007
Othman, Ahmed A; Newman, Amy Hauck; Eddington, Natalie D (2007) Applicability of the dopamine and rate hypotheses in explaining the differences in behavioral pharmacology of the chloro-benztropine analogs: studies conducted using intracerebral microdialysis and population pharmacodynamic modeling. J Pharmacol Exp Ther 322:760-9
Othman, Ahmed A; Syed, Shariq A; Newman, Amy H et al. (2007) Transport, metabolism, and in vivo population pharmacokinetics of the chloro benztropine analogs, a class of compounds extensively evaluated in animal models of drug abuse. J Pharmacol Exp Ther 320:344-53