The proposed research study seeks to use and expand an existing prospective longitudinal adoption study, the Early Growth and Development Study (EGDS: R01HD42608) to better understand how genetic factors, prenatal drug exposure, and postnatal rearing environment operate together to influence toddler development, and ultimately, an individual's risk of later drug use. We propose to recruit 200 yoked adoption units (birth parents and adoptive families linked through the adopted child - approximately 866 individuals) and to capitalize on the existing 350 yokes recruited by the EGDS study. The 550 total yokes (approximately 2,382 individuals) will provide sufficient power to examine possible interactions among genes, prenatal drug exposure and postnatal rearing environment that EGDS was not designed to study. Using the same assessment strategy and measurement as EGDS, the new 200 yokes will be followed longitudinally and DNA will be collected from all participants in the full sample of 550 yokes. This expanded sample and longitudinal assessment, combined with the collection of DNA, enables the examination of the following specific aims: (SA1) Understanding how genetic risk for later drug use is expressed behaviorally in the toddler period;(SA2) Estimating prenatal exposure effects independent of genetic risk;(SA3) Estimating postnatal family environmental effects independent of genetic risk and prenatal exposure;and (SA4) Clarifying how genetic risk and prenatal exposure to drugs are moderated by postnatal family environment. Integrating the three possible mechanisms of the transmission of drug abuse to children - genetic, prenatal exposure and postnatal environment - has important potential for informing public health. Specifically, the proposed study is designed to disentangle the effects of genetic, prenatal and postnatal environmental factors on early child development and to examine interactions and correlations among these factors. This will help guide intervention efforts aimed at the prevention of drug abuse in children of drug-dependent or drug-abusing parents by identifying which postnatal family environmental factors have the most impact on ameliorating risk from genetic and prenatal exposure factors.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA020585-04
Application #
7840534
Study Section
Behavioral Genetics and Epidemiology Study Section (BGES)
Program Officer
Boyce, Cheryl A
Project Start
2007-09-15
Project End
2012-05-31
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
4
Fiscal Year
2010
Total Cost
$948,451
Indirect Cost
Name
Pennsylvania State University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
003403953
City
University Park
State
PA
Country
United States
Zip Code
16802
Taraban, Lindsay; Shaw, Daniel S; Leve, Leslie D et al. (2017) Maternal depression and parenting in early childhood: Contextual influence of marital quality and social support in two samples. Dev Psychol 53:436-449
Klahr, Ashlea M; Burt, S Alexandra; Leve, Leslie D et al. (2017) Birth and Adoptive Parent Antisocial Behavior and Parenting: A Study of Evocative Gene-Environment Correlation. Child Dev 88:505-513
Brooker, R J; Alto, K M; Marceau, K et al. (2017) Early inherited risk for anxiety moderates the association between fathers' child-centered parenting and early social inhibition - CORRIGENDUM. J Dev Orig Health Dis 8:133
Waller, Rebecca; Shaw, Daniel S; Neiderhiser, Jenae M et al. (2017) Toward an Understanding of the Role of the Environment in the Development of Early Callous Behavior. J Pers 85:90-103
Grabow, Aleksandria Perez; Khurana, Atika; Natsuaki, Misaki N et al. (2017) Using an adoption-biological family design to examine associations between maternal trauma, maternal depressive symptoms, and child internalizing and externalizing behaviors. Dev Psychopathol 29:1707-1720
Massey, Suena H; Reiss, David; Neiderhiser, Jenae M et al. (2016) Maternal personality traits associated with patterns of prenatal smoking and exposure: Implications for etiologic and prevention research. Neurotoxicol Teratol 53:48-54
Marceau, Kristine; De Araujo-Greecher, Marielena; Miller, Emily S et al. (2016) The Perinatal Risk Index: Early Risks Experienced by Domestic Adoptees in the United States. PLoS One 11:e0150486
Mammen, Micah A; Moore, Ginger A; Scaramella, Laura V et al. (2016) Infant patterns of reactivity to tactile stimulation during parent-child interaction. Infant Behav Dev 44:121-32
Roos, Leslie E; Fisher, Philip A; Shaw, Daniel S et al. (2016) Inherited and environmental influences on a childhood co-occurring symptom phenotype: Evidence from an adoption study. Dev Psychopathol 28:111-25
Waller, Rebecca; Trentacosta, Christopher J; Shaw, Daniel S et al. (2016) Heritable temperament pathways to early callous-unemotional behaviour. Br J Psychiatry 209:475-482

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