The main objective of this project is to develop novel statistical methods for investigating heterogeneity in daily cocaine use trajectories among cocaine dependents.
The specific aims of this project are to: 1) derive informative summary measures for daily cocaine use trajectories and use such summary measures to subtype these trajectories;2) link posttreatment cocaine craving/stress and cocaine relapse to baseline variables while accounting for measurement error in the derived baseline summary measures;3) understand the dynamic relationship between posttreatment cocaine craving/stress and cocaine relapse;4) implement the developed statistical methods in a user-friendly computer package and make it available to the scientific community. To achieve these aims, we will develop cutting-edge statistical methods covering several areas including functional data analysis, measurement error and joint modeling of longitudinal and recurrent event data. Statistical properties of these methods will be thoroughly investigated through both rigorous theoretical derivation as well as extensive simulation. Specifically, the proposed functional data analysis techniques can help generate novel and more accurate subtypes for one's cocaine use patterns. The proposed methods accounting for measurement error can significantly reduce the potentially large bias in estimated regression coefficients due to measurement error and hence lead to more objective assessment of risk factors and treatment effect. The proposed statistical methods for modeling recurrent event processes allow us to make full use of the rich information contained in one's en- tire cocaine relapse trajectory, and thus can be more powerful in identifying risk factors as well as in detecting treatment effect. The proposed joint modeling of longitudinal and recurrent event data allows us to assess the relationship between cocaine relapse and time varying variables such as craving and stress. A greater understanding of this relationship can inspire the development of novel pharmacological strategies to treat cocaine dependence. In terms of statistical innovation, we introduce the novel concept of conducting functional data analysis for the mean and correlation structures of a stochastic process simultaneously, develop nonparametric methods to account for the measurement error when some predictors are derived from a stochastic process, and propose computationally efficient algorithms to jointly model longitudinal and recurrent event data.

Public Health Relevance

This project will develop novel statistical methods for investigating heterogeneity in daily cocaine use trajectories among cocaine dependents. Such analyses can significantly enhance our understanding of the causes for cocaine relapse by revealing important risk factors. They can also help assess the efficacy of treatment approaches by providing a more fine-tuned analysis to cocaine relapse trajectories.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA029081-04
Application #
8437264
Study Section
Biomedical Computing and Health Informatics Study Section (BCHI)
Program Officer
Kahana, Shoshana Y
Project Start
2011-01-15
Project End
2014-12-31
Budget Start
2013-01-01
Budget End
2014-12-31
Support Year
4
Fiscal Year
2013
Total Cost
$319,880
Indirect Cost
$100,732
Name
University of Miami Coral Gables
Department
Miscellaneous
Type
Other Domestic Higher Education
DUNS #
625174149
City
Coral Gables
State
FL
Country
United States
Zip Code
33146
Jiang, Yuan; Li, Ni; Zhang, Heping (2014) Identifying Genetic Variants for Addiction via Propensity Score Adjusted Generalized Kendall's Tau. J Am Stat Assoc 109:905-930
Jalilian, Abdollah; Guan, Yongtao; Waagepetersen, Rasmus (2013) Decomposition of Variance for Spatial Cox Processes. Scand Stat Theory Appl 40:119-137
Guan, Yongtao; Li, Yehua; Sinha, Rajita (2011) Cocaine Dependence Treatment Data: Methods for Measurement Error Problems With Predictors Derived From Stationary Stochastic Processes. J Am Stat Assoc 106:480-493