Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
3R01DC000090-21S1
Application #
3215636
Study Section
Hearing Research Study Section (HAR)
Project Start
1977-09-01
Project End
1992-11-30
Budget Start
1991-02-15
Budget End
1991-11-30
Support Year
21
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Ohio State University
Department
Type
Schools of Medicine
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210
Tong, Hua Hua; Chen, Yiping; Liu, Xia et al. (2008) Differential expression of cytokine genes and iNOS induced by nonviable nontypeable Haemophilus influenzae or its LOS mutants during acute otitis media in the rat. Int J Pediatr Otorhinolaryngol 72:1183-91
Tong, H H; Chen, Y; James, M et al. (2001) Expression of cytokine and chemokine genes by human middle ear epithelial cells induced by formalin-killed Haemophilus influenzae or its lipooligosaccharide htrB and rfaD mutants. Infect Immun 69:3678-84
Chen, Y P; Tong, H H; James et al. (2001) Detection of mucin gene expression in normal rat middle ear mucosa by reverse transcriptase-polymerase chain reaction. Acta Otolaryngol 121:45-51
Tong, H H; Blue, L E; James, M A et al. (2000) Evaluation of phase variation of nontypeable Haemophilus influenzae lipooligosaccharide during nasopharyngeal colonization and development of otitis media in the chinchilla model. Infect Immun 68:4593-7
Demaria, T F (1999) Localization of nontypeable Haemophilus influenzae endotoxin in the middle and inner ear during experimental otitis media. Acta Otolaryngol 119:583-7
Bakaletz, L O; White, G J; Post, J C et al. (1998) Blinded multiplex PCR analyses of middle ear and nasopharyngeal fluids from chinchilla models of single- and mixed-pathogen-induced otitis media. Clin Diagn Lab Immunol 5:219-24
DeMaria, T F; Apicella, M A; Nichols, W A et al. (1997) Evaluation of the virulence of nontypeable Haemophilus influenzae lipooligosaccharide htrB and rfaD mutants in the chinchilla model of otitis media. Infect Immun 65:4431-5
Bakaletz, L O; Holmes, K A (1997) Evidence for transudation of specific antibody into the middle ears of parenterally immunized chinchillas after an upper respiratory tract infection with adenovirus. Clin Diagn Lab Immunol 4:223-5
Bakaletz, L O; Leake, E R; Billy, J M et al. (1997) Relative immunogenicity and efficacy of two synthetic chimeric peptides of fimbrin as vaccinogens against nasopharyngeal colonization by nontypeable Haemophilus influenzae in the chinchilla. Vaccine 15:955-61
Miyamoto, N; Bakaletz, L O (1997) Kinetics of the ascension of NTHi from the nasopharynx to the middle ear coincident with adenovirus-induced compromise in the chinchilla. Microb Pathog 23:119-26

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