Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
2R01DC000200-14
Application #
2125079
Study Section
Hearing Research Study Section (HAR)
Project Start
1988-12-01
Project End
2000-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Virginia
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Mann, Zoƫ F; Thiede, Benjamin R; Chang, Weise et al. (2014) A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear. Nat Commun 5:3839
Burns, Joseph C; Corwin, Jeffrey T (2014) Responses to cell loss become restricted as the supporting cells in mammalian vestibular organs grow thick junctional actin bands that develop high stability. J Neurosci 34:1998-2011
Thiede, Benjamin R; Corwin, Jeffrey T (2014) Permeation of fluorophore-conjugated phalloidin into live hair cells of the inner ear is modulated by P2Y receptors. J Assoc Res Otolaryngol 15:13-30
Burns, Joseph C; Corwin, Jeffrey T (2013) A historical to present-day account of efforts to answer the question: ""what puts the brakes on mammalian hair cell regeneration?"". Hear Res 297:52-67
Burns, Joseph C; Collado, Maria Sol; Oliver, Eric R et al. (2013) Specializations of intercellular junctions are associated with the presence and absence of hair cell regeneration in ears from six vertebrate classes. J Comp Neurol 521:1430-48
Bermingham-McDonogh, Olivia; Corwin, Jeffrey T; Hauswirth, William W et al. (2012) Regenerative medicine for the special senses: restoring the inputs. J Neurosci 32:14053-7
Burns, Joseph C; On, Doan; Baker, Wendy et al. (2012) Over half the hair cells in the mouse utricle first appear after birth, with significant numbers originating from early postnatal mitotic production in peripheral and striolar growth zones. J Assoc Res Otolaryngol 13:609-27
Collado, Maria Sol; Burns, Joseph C; Meyers, Jason R et al. (2011) Variations in shape-sensitive restriction points mirror differences in the regeneration capacities of avian and mammalian ears. PLoS One 6:e23861
Collado, Maria Sol; Thiede, Benjamin R; Baker, Wendy et al. (2011) The postnatal accumulation of junctional E-cadherin is inversely correlated with the capacity for supporting cells to convert directly into sensory hair cells in mammalian balance organs. J Neurosci 31:11855-66
Goodyear, Richard J; Legan, P Kevin; Christiansen, Jeffrey R et al. (2010) Identification of the hair cell soma-1 antigen, HCS-1, as otoferlin. J Assoc Res Otolaryngol 11:573-86

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