This proposal seeks funding for continuing studies of the structural and functional embryology of the auditory system. Embryological experiments will be conducted on the brainstem auditory pathways of the chick. They will concentrate on early embryological events involving cellular interactions that may underlie the development of topographic registry between successive regions of the auditory pathways. State-of-the-art microscopic and cell-marking methods will be used to investigate cell migration and axonal terminal field formation. Functional development will be examined in the inner ear and cochlear nucleus of gerbils. Experiments are designed to examine the development of high frequency hearing and to investigate relationships between the ontogeny of mature hearing, place- code development, and nonlinear """"""""active"""""""" properties of the inner ear. Ontogenetic properties of otoacoustic emissions will be examined before and after elimination of the endocochlear potential in order to examine contributions of different cochlear mechanisms to the development of mature information processing by the inner ear.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC000395-14
Application #
6030158
Study Section
Hearing Research Study Section (HAR)
Project Start
1986-07-01
Project End
2000-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
14
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Washington
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Sorensen, Staci A; Rubel, Edwin W (2011) Relative input strength rapidly regulates dendritic structure of chick auditory brainstem neurons. J Comp Neurol 519:2838-51
Seidl, Armin H; Rubel, Edwin W; Harris, David M (2010) Mechanisms for adjusting interaural time differences to achieve binaural coincidence detection. J Neurosci 30:70-80