Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC001362-05
Application #
2126427
Study Section
Hearing Research Study Section (HAR)
Project Start
1992-01-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Physiology
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Beurg, Maryline; Cui, Runjia; Goldring, Adam C et al. (2018) Variable number of TMC1-dependent mechanotransducer channels underlie tonotopic conductance gradients in the cochlea. Nat Commun 9:2185
Wu, Zizhen; Grillet, Nicolas; Zhao, Bo et al. (2017) Mechanosensory hair cells express two molecularly distinct mechanotransduction channels. Nat Neurosci 20:24-33
Giese, Arnaud P J; Tang, Yi-Quan; Sinha, Ghanshyam P et al. (2017) CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells. Nat Commun 8:43
Fettiplace, Robert (2017) Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea. Compr Physiol 7:1197-1227
Beurg, Maryline; Fettiplace, Robert (2017) PIEZO2 as the anomalous mechanotransducer channel in auditory hair cells. J Physiol 595:7039-7048
Beurg, Maryline; Goldring, Adam C; Ricci, Anthony J et al. (2016) Development and localization of reverse-polarity mechanotransducer channels in cochlear hair cells. Proc Natl Acad Sci U S A 113:6767-72
Fettiplace, Robert (2016) Is TMC1 the Hair Cell Mechanotransducer Channel? Biophys J 111:3-9
Beurg, Maryline; Goldring, Adam C; Fettiplace, Robert (2015) The effects of Tmc1 Beethoven mutation on mechanotransducer channel function in cochlear hair cells. J Gen Physiol 146:233-43
Beurg, Maryline; Xiong, Wei; Zhao, Bo et al. (2015) Subunit determination of the conductance of hair-cell mechanotransducer channels. Proc Natl Acad Sci U S A 112:1589-94
Beurg, Maryline; Kim, Kyunghee X; Fettiplace, Robert (2014) Conductance and block of hair-cell mechanotransducer channels in transmembrane channel-like protein mutants. J Gen Physiol 144:55-69

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