The long term goal of this research is to establish a theoretical basis for understanding sensorimotor control in posture, including behavior and its underlying physiology. A focus in the present application will be the relationship of neural activity in the cerebellum to postural control. The methods will be entirely theoretical, and a major objective of the research will be to develop a mathematical structure describing the postural control system. The work will be accomplished with the collaboration of experimental physiologists. To achieve this goal, components of strategies that reduce the number of sensorimotor control parameters will be identified, given a set of task requirements such as maintaining stability. Then the components of strategies will be represented as relations between classes of stimuli and motor commands. Since classes of stimuli can also be equivalent for a population of neurons, populations of neurons will be identified whose activity expresses the same equivalence of classes of stimuli and motor commands. Specifically, patterns of neural activity in the cerebellum will be constructed using receptive field data, in order ultimately to determine to what extent populations of active cells in the cerebellum are directly controlling posture. A mathematical structure will be developed to describe postural control at both the behavioral and the neural-activity levels. Results of this research will clarify the unified nature of postural behavior and its underlying physiology, and will provide a more rational basis for diagnosis and treatment of balance disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
9R01DC002482-09
Application #
2127860
Study Section
Hearing Research Study Section (HAR)
Project Start
1993-12-11
Project End
1997-02-28
Budget Start
1994-03-01
Budget End
1995-02-28
Support Year
9
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Good Samaritan Hosp & Medical Center(Prtlnd,OR)
Department
Type
DUNS #
City
Portland
State
OR
Country
United States
Zip Code
97210
Roberts, P D (1999) Computational consequences of temporally asymmetric learning rules: I. Differential hebbian learning. J Comput Neurosci 7:235-46
Holly, J E; McCollum, G; Boyle, R (1999) Identification of head motions by central vestibular neurons receiving linear and angular input. Biol Cybern 81:177-88
McCollum, G (1999) Sensory and motor interdependence in postural adjustments. J Vestib Res 9:303-25
Holly, J E; McCollum, G (1998) Timing of secondary vestibular neuron responses to a range of rotational head movements. Biol Cybern 79:39-48
Roberts, P D (1998) Classification of temporal patterns in dynamic biological networks. Neural Comput 10:1831-46
Holly, J E (1997) Three-dimensional baselines for perceived self-motion during acceleration and deceleration in a centrifuge. J Vestib Res 7:45-61
Roberts, P D (1997) Classification of rhythmic patterns in the stomatogastric ganglion. Neuroscience 81:281-96
Roberts, P D; McCollum, G (1996) Dynamics of the sit-to-stand movement. Biol Cybern 74:147-57
Holly, J E; McCollum, G (1996) The shape of self-motion perception--II. framework and principles for simple and complex motion. Neuroscience 70:487-513
McCollum, G; Shupert, C L; Nashner, L M (1996) Organizing sensory information for postural control in altered sensory environments. J Theor Biol 180:257-70

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