The overall long-term objective of this research program is to understand the involvement of the primary auditory cortex (A1) in auditory associative memory (AAM) and to identify mechanisms of AAM. In contrast to traditional views that A1 is strictly an acoustic analyzer, contemporary research has established that learning modifies the processing, representation and storage of acoustic information in highly-specific ways, to emphasize behaviorally important sounds.
The specific aims of the experiments are to determine (1) the factors that govern the type, degree and retention of specific cortical plasticity, including learning strategy, amount of training and type of acoustic stimulus, (2) the nature of the development of plasticity during training and its long term-retention and (3) the attributes of auditory associative memory that is induced by sound paired with activation of the cholinergic nucleus basalis (NB). Rats will be trained in a variety of acoustically-based tasks involving detailed recording of neuronal discharges in A1 either during various stages of learning or comprehensive mapping of A1 after the completion of learning tasks. To test the hypothesis that activation of the cholinergic system is involved in the induction of normal auditory memory, we will determine if NB- induced memory also is capable of long-term retention, discrimination, and transfer to new situations. The findings will elucidate cortical mnemonic function and provide a foundation for therapeutic treatments including experience-dependent recovery of higher auditory function following insult, and learning to perceive speech following cochlear implant treatments. These findings will significantly increase our understanding of a fundamental aspect of auditory cortical function, that of experience-based neural plasticity. Therefore, they will be highly relevant both to the central issue of how features of sound interact with experience to produce auditory comprehension, and for therapeutic treatments of auditory system impairment and learning to understand speech via prosthetic means such as cochlear implants.

Public Health Relevance

These findings will significantly increase our understanding of a fundamental aspect of auditory cortical function, that of experience-based neural plasticity. Therefore, they will be highly relevant both to the central issue of how features of sound interact with experience to produce auditory comprehension, and for therapeutic treatments of auditory system impairment and learning to understand speech via prosthetic means such as cochlear implants.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC002938-15
Application #
8464689
Study Section
Auditory System Study Section (AUD)
Program Officer
Platt, Christopher
Project Start
1997-08-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
15
Fiscal Year
2013
Total Cost
$287,532
Indirect Cost
$94,072
Name
University of California Irvine
Department
Other Basic Sciences
Type
Schools of Arts and Sciences
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Weinberger, Norman M; Miasnikov, Alexandre A; Bieszczad, Kasia M et al. (2013) Gamma band plasticity in sensory cortex is a signature of the strongest memory rather than memory of the training stimulus. Neurobiol Learn Mem 104:49-63
Bieszczad, Kasia M; Kant, Ritu; Constantinescu, Cristian C et al. (2012) Nicotinic acetylcholine receptors in rat forebrain that bind ýýýýýF-nifene: relating PET imaging, autoradiography, and behavior. Synapse 66:418-34
Headley, Drew B; Weinberger, Norman M (2011) Gamma-band activation predicts both associative memory and cortical plasticity. J Neurosci 31:12748-58
Miasnikov, Alexandre A; Chen, Jemmy C; Weinberger, Norman M (2011) Consolidation and long-term retention of an implanted behavioral memory. Neurobiol Learn Mem 95:286-95
Weinberger, Norman M (2011) The medial geniculate, not the amygdala, as the root of auditory fear conditioning. Hear Res 274:61-74
Weinberger, Norman M; Miasnikov, Alexandre A; Chen, Jemmy C (2009) Sensory memory consolidation observed: increased specificity of detail over days. Neurobiol Learn Mem 91:273-86
Miasnikov, Alexandre A; Chen, Jemmy C; Weinberger, Norman M (2009) Behavioral memory induced by stimulation of the nucleus basalis: effects of contingency reversal. Neurobiol Learn Mem 91:298-309
Hui, Gabriel K; Wong, Kwan L; Chavez, Candice M et al. (2009) Conditioned tone control of brain reward behavior produces highly specific representational gain in the primary auditory cortex. Neurobiol Learn Mem 92:27-34
Miasnikov, Alexandre A; Chen, Jemmy C; Gross, Nataliya et al. (2008) Motivationally neutral stimulation of the nucleus basalis induces specific behavioral memory. Neurobiol Learn Mem 90:125-37
Miasnikov, Alexandre A; Chen, Jemmy C; Weinberger, Norman M (2008) Specific auditory memory induced by nucleus basalis stimulation depends on intrinsic acetylcholine. Neurobiol Learn Mem 90:443-54

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