Speech sounds are the most important sounds that we hear;yet little is known about how these stimuli are represented by neural activity within human auditory cortex. The goal of our research is to understand the functional organization and connections of those areas of human cerebral cortex that are engaged in sound processing and examine how auditory speech stimuli are represented in these regions. These experiments involve combining anatomical and functional MRI methods with direct cortical electrophysiological recordings and electrical stimulation techniques in awake, behaving human subjects undergoing clinical evaluation of intractable epilepsy. We will pursue our goals by testing a series of specific hypotheses regarding: (1) the locations and functional properties of auditory cortical fields;(2) the manner in which evoked responses to speech stimuli are represented and transformed within these fields;and (3) the functional connections and patterns of information flow between these fields. These objectives are pursued by an experienced multidisciplinary team using combinations of non-invasive MRI and direct investigative methods in order to gather complementary sets of human physiological and anatomical data in the same experimental subjects. These data cannot be obtained using non-invasive methods alone, and this multi-modal experimental approach is designed to overcome significant barriers that currently impede research progress in this field. To our knowledge, if our objectives are achieved, the resulting data will be the first of its kind demonstrating directly how acoustic and phonetic speech information is represented by neural activity within multiple physiologically-defined auditory fields of the superior temporal plane and lateral superior temporal gyrus as subjects engage in psychophysical speech-processing tasks. We pursue these research objectives believing that knowledge of the fundamental structure and function of the normal human auditory system is essential to understanding mechanism that underlie impairment of all aspects of hearing, speech, and language.

Public Health Relevance

This research program generates unique information about the functional organization of human auditory cortex that cannot be obtained using alternative, non-invasive approaches. Knowledge gained from these studies will provide new insights into how speech information is represented within the human brain and aid in the rational design of new therapeutic and rehabilitation strategies for patients affected by a wide range of communication disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC004290-13
Application #
8384845
Study Section
Auditory System Study Section (AUD)
Program Officer
Donahue, Amy
Project Start
1999-12-01
Project End
2015-11-30
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
13
Fiscal Year
2013
Total Cost
$545,350
Indirect Cost
$120,967
Name
University of Iowa
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Sedley, William; Gander, Phillip E; Kumar, Sukhbinder et al. (2016) Neural signatures of perceptual inference. Elife 5:e11476
Rhone, Ariane E; Nourski, Kirill V; Oya, Hiroyuki et al. (2016) Can you hear me yet? An intracranial investigation of speech and non-speech audiovisual interactions in human cortex. Lang Cogn Neurosci 31:284-302
Nourski, Kirill V; Steinschneider, Mitchell; Rhone, Ariane E (2016) Electrocorticographic Activation within Human Auditory Cortex during Dialog-Based Language and Cognitive Testing. Front Hum Neurosci 10:202
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Behroozmand, Roozbeh; Oya, Hiroyuki; Nourski, Kirill V et al. (2016) Neural Correlates of Vocal Production and Motor Control in Human Heschl's Gyrus. J Neurosci 36:2302-15
Ai, Leo; Xiong, Jinhu (2016) Temporal-spatial mean-shift clustering analysis to improve functional MRI activation detection. Magn Reson Imaging 34:1283-1291
Long, Michael A; Katlowitz, Kalman A; Svirsky, Mario A et al. (2016) Functional Segregation of Cortical Regions Underlying Speech Timing and Articulation. Neuron 89:1187-93
Abel, Taylor J; Rhone, Ariane E; Nourski, Kirill V et al. (2016) Beta modulation reflects name retrieval in the human anterior temporal lobe: an intracranial recording study. J Neurophysiol 115:3052-61
Sedley, William; Gander, Phillip E; Kumar, Sukhbinder et al. (2015) Intracranial Mapping of a Cortical Tinnitus System using Residual Inhibition. Curr Biol 25:1208-14
Kingyon, J; Behroozmand, R; Kelley, R et al. (2015) High-gamma band fronto-temporal coherence as a measure of functional connectivity in speech motor control. Neuroscience 305:15-25

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