The long-term goal of our investigations is to understand the functional role of certain neuronal subtypes in the processing of sound in the cortex. Understanding this circuitry is likely to have an impact on the diagnosis and treatment of clinically important cortical neuropathologies, including autism, schizophrenia, tinnitus and epilepsy. Our central hypothesis is that a certain subtype of inhibitory neuron plays an important role in determining how other cortical neurons respond to sound. To achieve our goals, we propose to monitor and perturb the activity of these neurons.
In aim 1, we will study this circuit in vitro, substituting electrical for auditory stimulation.
In aims 2 and 3 we will study this circuit in vivo, presenting simple sounds and monitoring the responses they elicit in single neurons, and looking at their role in an auditory behavior. If successful, our studies will provide the link between molecular, circuit and functional aspects of sound processing in the auditory system, and will facilitate the development of treatments for psychiatric and neurological diseases. This proposal will test the function of a particular class of cortical neurons implicated in the etiology of clinically important neuropathologies, including autism, schizophrenia, tinnitus and epilepsy. If successful, our studies will lead to improved strategies for diagnosing and treating these and related disorders.

Public Health Relevance

This proposal will test the function of a particular class of cortical neurons implicated in the etiology of clinically important neuropathologies, including autism, schizophrenia, tinnitus and epilepsy. If successful, our studies will lead to improved strategies for diagnosing and treating these and related disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC005415-10
Application #
8302391
Study Section
Auditory System Study Section (AUD)
Program Officer
Platt, Christopher
Project Start
2002-04-01
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2014-07-31
Support Year
10
Fiscal Year
2012
Total Cost
$354,339
Indirect Cost
$150,696
Name
Cold Spring Harbor Laboratory
Department
Type
DUNS #
065968786
City
Cold Spring Harbor
State
NY
Country
United States
Zip Code
11724
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Hromadka, Tomas; Zador, Anthony M; DeWeese, Michael R (2013) Up states are rare in awake auditory cortex. J Neurophysiol 109:1989-95
Jaramillo, Santiago; Zador, Anthony M (2011) The auditory cortex mediates the perceptual effects of acoustic temporal expectation. Nat Neurosci 14:246-51
Hromadka, Tomas; Zador, Anthony M (2009) Representations in auditory cortex. Curr Opin Neurobiol 19:430-3
Bledsoe Jr, Sanford C; Koehler, Seth; Tucci, Debara L et al. (2009) Ventral cochlear nucleus responses to contralateral sound are mediated by commissural and olivocochlear pathways. J Neurophysiol 102:886-900
Hromadka, Tomas; Zador, Anthony M (2007) Toward the mechanisms of auditory attention. Hear Res 229:180-5
Sumner, Christian J; Tucci, Debara L; Shore, Susan E (2005) Responses of ventral cochlear nucleus neurons to contralateral sound after conductive hearing loss. J Neurophysiol 94:4234-43