The overall objective of the proposed research is to reveal physiological mechanisms underlying auditory-vocal interaction in non-human primates. Such mechanisms have fundamental importance to our understanding of human speech production and perception mechanisms but are poorly understood, and there are no adequate non-human primate models available to address these issues at the cellular level. In this application, we will examine our research questions in a highly vocal primate, the common marmoset (Callithrix jacchus). The marmoset provides several important advantages over other non-human primate species: a rich vocal repertoire, a high reproductive rate while in captivity, and a smooth brain allowing easy access to all parts of the cerebral cortex. In the proposed experiments, we will focus on neural substrates of auditory-vocal interactions in marmoset auditory cortex.
In Aim 1, we will develop a behavioral paradigm to experimentally induce vocalizations in the common marmoset. The ability to behaviorally (not electrically) elicit vocalizations in monkeys has long been sought by researchers and remains a significant obstacle in the study of vocal control mechanisms in non-human primates. We will study in Aim 2 how various areas of the auditory cortex are involved in auditory-vocal interactions. Findings from this aim will reveal functional and anatomical properties of neurons involved in auditory-vocal interactions in marmoset auditory cortex, and pave the way for future studies of their connectivity with the brain structures involved in vocal production.
In Aim 3, we will study the role of behavioral context in auditory-vocal interactions within auditory cortex. Marmosets produce a wide range of vocalizations in different behavioral contexts. We will investigate whether different types of vocalizations produce different modulatory effects in individual auditory cortical neurons. Findings of this research will provide important insight into speech perception mechanisms in humans and establish a non-human primate model to investigate issues related to diseases and dysfunctions in speech and hearing.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC005808-07
Application #
7743375
Study Section
Auditory System Study Section (AUD)
Program Officer
Platt, Christopher
Project Start
2003-01-01
Project End
2011-11-30
Budget Start
2009-12-01
Budget End
2010-11-30
Support Year
7
Fiscal Year
2010
Total Cost
$340,530
Indirect Cost
Name
Johns Hopkins University
Department
Biomedical Engineering
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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Wang, Xiaoqin (2016) The Ying and Yang of Auditory Nerve Damage. Neuron 89:680-2
Osmanski, Michael S; Song, Xindong; Guo, Yueqi et al. (2016) Frequency discrimination in the common marmoset (Callithrix jacchus). Hear Res 341:1-8
Roy, Sabyasachi; Zhao, Lingyun; Wang, Xiaoqin (2016) Distinct Neural Activities in Premotor Cortex during Natural Vocal Behaviors in a New World Primate, the Common Marmoset (Callithrix jacchus). J Neurosci 36:12168-12179
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Zhou, Yi; Wang, Xiaoqin (2014) Spatially extended forward suppression in primate auditory cortex. Eur J Neurosci 39:919-33
Bartlett, Edward L (2013) The organization and physiology of the auditory thalamus and its role in processing acoustic features important for speech perception. Brain Lang 126:29-48
Eliades, Steven J; Wang, Xiaoqin (2013) Comparison of auditory-vocal interactions across multiple types of vocalizations in marmoset auditory cortex. J Neurophysiol 109:1638-57

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