Voice disorders are among the most prevalent disorders affecting people with communication disabilities. People afflicted with these disorders have difficulty communication with others, the disorders may adversely affect their careers, and the people often become socially isolated. There is little we can do to prevent these disorders without a solid understanding of their cause. Part of the reason for this lack of understanding is because of the lack of basic knowledge of normal voice control mechanisms. Recent research has shown that sensory feedback plays an important role in voice control. The overall goal of this research project is to understand the neural mechanisms involved in voice control. We have learned over the past several years that as people are vocalizing or speaking, that experimental manipulation of their voice auditory feedback causes a reflexive change in their voice fundamental frequency (F0) or amplitude. We have also learned that people with Parkinson's disease or children with autism have unusually large responses to these manipulations. These observations indicate that neural mechanisms involved in generating responses to perturbations in voice auditory feedback are abnormal in some neurological disorders. For this reason it is necessary to learn how the brain controls the responses to perturbations in voice feedback. In the proposed studies, we will record electrical potentials from the brain surface in patients being treated with epilepsy. We will also obtain images of the blood flow changes in subjects as they respond to perturbations in voice auditory feedback (fMRI). We will then magnetically stimulate those areas of the brain shown to be active in this process, which will temporarily change neural functioning in those areas known to be active during the reflexes. We will develop a model, based on the responses to magnetic stimulation, of the connections within the brain that are involved in the reflexive responses. These data will allow us to develop more specific hypotheses on how each of several areas of the brain are involved in the responses to perturbations in voice auditory feedback.
This research project will improve our understanding of brain mechanisms involved in voice control. This understanding will lead to new diagnostic and therapeutic procedures for patients suffering from voice disorders.
|Korzyukov, Oleg; Tapaskar, Natalie; Pflieger, Mark E et al. (2015) Event related potentials study of aberrations in voice control mechanisms in adults with attention deficit hyperactivity disorder. Clin Neurophysiol 126:1159-70|
|Patel, Sona; Nishimura, Cristina; Lodhavia, Anjli et al. (2014) Understanding the mechanisms underlying voluntary responses to pitch-shifted auditory feedback. J Acoust Soc Am 135:3036-44|
|Manes, Jordan L; Parkinson, Amy L; Larson, Charles R et al. (2014) Connectivity of the subthalamic nucleus and globus pallidus pars interna to regions within the speech network: a meta-analytic connectivity study. Hum Brain Mapp 35:3499-516|
|Behroozmand, Roozbeh; Ibrahim, Nadine; Korzyukov, Oleg et al. (2014) Left-hemisphere activation is associated with enhanced vocal pitch error detection in musicians with absolute pitch. Brain Cogn 84:97-108|
|Flagmeier, Sabina G; Ray, Kimberly L; Parkinson, Amy L et al. (2014) The neural changes in connectivity of the voice network during voice pitch perturbation. Brain Lang 132:7-13|
|Parkinson, Amy L; Korzyukov, Oleg; Larson, Charles R et al. (2013) Modulation of effective connectivity during vocalization with perturbed auditory feedback. Neuropsychologia 51:1471-80|
|Greenlee, Jeremy D W; Behroozmand, Roozbeh; Larson, Charles R et al. (2013) Sensory-motor interactions for vocal pitch monitoring in non-primary human auditory cortex. PLoS One 8:e60783|
|Behroozmand, Roozbeh; Korzyukov, Oleg; Larson, Charles R (2012) ERP correlates of pitch error detection in complex tone and voice auditory feedback with missing fundamental. Brain Res 1448:89-100|
|Chen, Zhaocong; Liu, Peng; Wang, Emily Q et al. (2012) ERP correlates of language-specific processing of auditory pitch feedback during self-vocalization. Brain Lang 121:25-34|
|Korzyukov, Oleg; Karvelis, Laura; Behroozmand, Roozbeh et al. (2012) ERP correlates of auditory processing during automatic correction of unexpected perturbations in voice auditory feedback. Int J Psychophysiol 83:71-8|
Showing the most recent 10 out of 35 publications