The overall aim of this project is to understand the neural mechanisms of sound localization and selective auditory attention. These results will help to understand how the brain integrates auditory information from the two ears and how it can direct attention to one source over others in a noisy environment. This circuitry plays a major role in our ability to detect signals in the presence of background noise, which is the major symptom of elderly people with hearing loss. Understanding the neural mechanisms will help in the design of hearing aids and therapy. There are two major aims. First, we will use two well-known spatial auditory illusions to study the representation of sound sources in space in the inferior colliculus. Experiments will use a combined behavioral and physiological preparation in awake and trained cats. We will continue our on-going experiments on the psychophysics and physiology of the precedence effect and begin a new series of experiments on the Franssen effect. Both of these are robust auditory illusions that can be readily demonstrated in our behaving preparation. Second, we will develop a new psychophysical paradigm for studying selective auditory attention. Cats will be trained to attend to a speaker on one side in order to make frequency discriminations while ignoring sounds from the contralateral side. We hypothesize that attending to one side will enhance the ability to perform the discrimination as compared to trials in which the animal is not cued to attend to one side or the other. We will then make physiological recordings from the auditory cortex using an innovative silicone multichannel probe to look for modulation by attention during this task. Spatial hearing and selective attention are important basic functions of the auditory system: defects in binaural function in human patients can lead to considerable difficulty in understanding conversations in a noisy room, which is the most common complaint of the hearing-impaired and can lead to severe social withdrawal.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC007177-02
Application #
6986196
Study Section
Auditory System Study Section (AUD)
Program Officer
Luethke, Lynn E
Project Start
2004-12-01
Project End
2009-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
2
Fiscal Year
2006
Total Cost
$281,320
Indirect Cost
Name
University of Wisconsin Madison
Department
Physiology
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Ruhland, Janet L; Jones, Amy E; Yin, Tom C T (2015) Dynamic sound localization in cats. J Neurophysiol 114:958-68
Gai, Yan; Ruhland, Janet L; Yin, Tom C T (2015) Behavior and modeling of two-dimensional precedence effect in head-unrestrained cats. J Neurophysiol 114:1272-85
Gai, Yan; Ruhland, Janet L; Yin, Tom C T (2014) Localization of click trains and speech by cats: the negative level effect. J Assoc Res Otolaryngol 15:789-800
Jones, Amy E; Ruhland, Janet L; Gai, Yan et al. (2014) Simultaneous comparison of two sound localization measures. Hear Res 317:33-40
Tollin, Daniel J; Ruhland, Janet L; Yin, Tom C T (2013) The role of spectral composition of sounds on the localization of sound sources by cats. J Neurophysiol 109:1658-68
Gai, Yan; Ruhland, Janet L; Yin, Tom C T et al. (2013) Behavioral and modeling studies of sound localization in cats: effects of stimulus level and duration. J Neurophysiol 110:607-20
Ruhland, Janet L; Yin, Tom C T; Tollin, Daniel J (2013) Gaze shifts to auditory and visual stimuli in cats. J Assoc Res Otolaryngol 14:731-55
Gai, Yan; Ruhland, Janet L; Yin, Tom C T (2013) Effects of forward masking on sound localization in cats: basic findings with broadband maskers. J Neurophysiol 110:1600-10
Karino, Shotaro; Smith, Philip H; Yin, Tom C T et al. (2011) Axonal branching patterns as sources of delay in the mammalian auditory brainstem: a re-examination. J Neurosci 31:3016-31
Tollin, Daniel J; McClaine, Elizabeth M; Yin, Tom C T (2010) Short-latency, goal-directed movements of the pinnae to sounds that produce auditory spatial illusions. J Neurophysiol 103:446-57

Showing the most recent 10 out of 13 publications