Permanent childhood hearing loss, which occurs in 1-2/1000 live-births, has negative impacts on children's lives, at high societal cost. Universal newborn hearing screening (UNHS) offers hope for early treatment. However, UNHS is costly, and evidence of its effectiveness in improving long-term outcomes, at a population level, was lacking. By capitalizing on a unique service and research environment in Australia - where children access uniform hearing services from a single provider (Australian Hearing, AH) but had differential access to UNHS during a narrow time window - we addressed the evidence gap by conducting the Longitudinal Outcomes of Children with Hearing Impairment (LOCHI) study. The funding from NIH enabled us to assemble a population-based cohort of 450 children with significant bilateral hearing loss (53% fitted with hearing aids before 6 months of age). We measured their outcomes from diagnosis to 5 years of age. We found that early implantation was positively linked to better outcomes for profound loss, but early hearing aid fitting had limited gains for children with less severe loss. As the cohort ages, the effectiveness of UNHS may alter as benefits in additional domains may be measured. In showing the limited gains made by UNHS and early fitting alone, our findings galvanize new research into how to effectively intervene to capitalize on early treatment for improving outcomes. This application is for Phase 2 of the LOCHI study. The objectives are to investigate the efficacy of early intervention for improving long-term population outcomes, across the entire spectrum of hearing loss: children with mild or unilateral hearing loss (MUHL), which occurs in 1-2/1000 live-births, are also identified via UNHS but for whom audiological treatment is controversial. We propose to measure outcomes of the LOCHI cohort at age 9 years in an expanded range of domains;and to include a randomized controlled trial of intervention for a new cohort of children with MUHL.
Our specific aims are: 1) describe the speech, language, literacy, mental health and quality of life of children who received early or later intervention;2) identify modifiable factors that influence performance outcomes and standard score trajectories;3) determine predictability of early outcomes for later development to identify the critical age at which children with poor outcomes at age 9 years can be reliably detected;and 4) investigate cognitive abilities and learning strategies of children. All outcomes data and a wide range of predictors will be evaluated in multiple regression analyses. The data and results will be incorporated in a software tool that we will develop to facilitate clinical use. As the research arm of AH, we will minimise loss to follow up by maintaining contact via the service provision network. Achieving the aims will provide the evidence base to 1) guide best-practice intervention following diagnosis across the spectrum of hearing loss;and 2) demonstrate outcomes affected by access to early intervention.

Public Health Relevance

This study examines the effectiveness of universal newborn hearing screening (UNHS) by taking advantage of a unique research and service environment in Australia to conduct a population-based study comparing outcomes of early- and late-identified children in a prospective manner. This study will generate definitive evidence on the impact of congenital permanent hearing loss on children's development over the first 10 years of life;and determine factors affecting outcomes and rate of growth. It will also provide evidence on the impact of mild or unilateral hearing loss and the efficacy of early intervention. The findings will translate to improved population health by providing evidence on which to base clinical service delivery. The study will also assist future public health research in the field of hearing loss by means of making available a population-based cohort of early- and late-identified individuals with congenital hearing loss who can be followed longitudinally.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
2R01DC008080-06
Application #
8629658
Study Section
Language and Communication Study Section (LCOM)
Program Officer
Donahue, Amy
Project Start
2006-01-02
Project End
2019-01-31
Budget Start
2014-02-06
Budget End
2015-01-31
Support Year
6
Fiscal Year
2014
Total Cost
$316,532
Indirect Cost
Name
Australian Hearing Services
Department
Type
DUNS #
751653940
City
Macquarie University
State
Country
Australia
Zip Code
NSW 2-109
Wake, Melissa; Ching, Teresa Y C; Wirth, Karen et al. (2016) Population Outcomes of Three Approaches to Detection of Congenital Hearing Loss. Pediatrics 137:
Ching, Teresa Y C; Zhang, Vicky W; Hou, Sanna et al. (2016) Cortical Auditory Evoked Potentials Reveal Changes in Audibility with Nonlinear Frequency Compression in Hearing Aids for Children: Clinical Implications. Semin Hear 37:25-35
Cupples, Linda; Ching, Teresa Y C; Button, Laura et al. (2016) Language and speech outcomes of children with hearing loss and additional disabilities: identifying the variables that influence performance at five years of age. Int J Audiol :1-12
Erbasi, Ennur; Scarinci, Nerina; Hickson, Louise et al. (2016) Parental involvement in the care and intervention of children with hearing loss. Int J Audiol :1-12
Wong, Cara L; Ching, Teresa Y; Leigh, Greg et al. (2016) Psychosocial development of 5-year-old children with hearing loss: Risks and protective factors. Int J Audiol :1-12
Leigh, Greg; Ching, Teresa Y C; Crowe, Kathryn et al. (2015) Factors Affecting Psychosocial and Motor Development in 3-Year-Old Children Who Are Deaf or Hard of Hearing. J Deaf Stud Deaf Educ 20:331-42
Ching, Teresa Y C; Cupples, Linda (2015) Phonological Awareness at 5 years of age in Children who use Hearing Aids or Cochlear Implants. Perspect Hear Hear Disord Child 25:48-59
Ching, Teresa Y C (2015) Is Early Intervention Effective in Improving Spoken Language Outcomes of Children With Congenital Hearing Loss? Am J Audiol 24:345-8
Marnane, Vivienne; Ching, Teresa Y C (2015) Hearing aid and cochlear implant use in children with hearing loss at three years of age: Predictors of use and predictors of changes in use. Int J Audiol 54:544-51
Crowe, Kathryn; McLeod, Sharynne; McKinnon, David H et al. (2015) Attitudes toward the capabilities of deaf and hard of hearing adults: insights from the parents of deaf and hard of hearing children. Am Ann Deaf 160:24-35

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