What is the relationship between the human faculty for language and the many other, nonlinguistic cognitive abilities we possess? For the past decade, our research team has explored this important question by focusing on a place (quite literally) where linguistic and nonlinguistic processes seem to "meet":Broca's area. Long described of as the seat of some linguistic specialization, Broca's area may have more in common with the rest of prefrontal cortex than is typically thought. Motivated by an extensive literature on the regulatory functions of prefrontal cortex, we have developed a framework for considering the role of Broca's area - a part of prefrontal cortex - in language processing. Weargue that Broca's area functions to bias competitive interactions among representations of many types (including semantic, phonological, and syntactic). As such, the relationship between Broca's area and linguistic function cannot be captured by studying a single domain (such as syntax) but rather requires the broad, interdisciplinary approach represented in our research program and exemplified by the divergent expertise of our researchteam. In the coming years of this research program, we hope to continue our multi-method investigations of linguistic and nonlinguistic functions of prefrontal cortex. The major aims of the research plans outlined in the current proposal are as follows: (1) to continue our investigations of the role of LIFG in language processing;(2) to better characterize the role of LIFG in working memory;(3) to evaluate the relation between working memory, language, and cognitive control and the nature of their dependence on LIFG;and, (4) to develop new tools for inferring causal structure-function relations. This research program has relevance to disorders of mental health (specifically, attentional disorders) and to disorders of language, by virtue of the fact that it highlights the important links between these two seemingly disparate functions.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Research Project (R01)
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Cognition and Perception Study Section (CP)
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Shekim, Lana O
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University of Pennsylvania
Schools of Arts and Sciences
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Musz, Elizabeth; Thompson-Schill, Sharon L (2015) Semantic variability predicts neural variability of object concepts. Neuropsychologia 76:41-51
Musz, Elizabeth; Weber, Matthew J; Thompson-Schill, Sharon L (2015) Visual statistical learning is not reliably modulated by selective attention to isolated events. Atten Percept Psychophys 77:78-96
Nozari, Nazbanou; Woodard, Kristina; Thompson-Schill, Sharon L (2014) Consequences of cathodal stimulation for behavior: when does it help and when does it hurt performance? PLoS One 9:e84338
Nozari, Nazbanou; Arnold, Jennifer E; Thompson-Schill, Sharon L (2014) The effects of anodal stimulation of the left prefrontal cortex on sentence production. Brain Stimul 7:784-92
Coutanche, Marc N; Thompson-Schill, Sharon L (2014) Using informational connectivity to measure the synchronous emergence of fMRI multi-voxel information across time. J Vis Exp :
Fedorenko, Evelina; Thompson-Schill, Sharon L (2014) Reworking the language network. Trends Cogn Sci 18:120-6
Weber, Matthew J; Detre, John A; Thompson-Schill, Sharon L et al. (2013) Reproducibility of functional network metrics and network structure: a comparison of task-related BOLD, resting ASL with BOLD contrast, and resting cerebral blood flow. Cogn Affect Behav Neurosci 13:627-40
Chrysikou, Evangelia G; Hamilton, Roy H; Coslett, H Branch et al. (2013) Noninvasive transcranial direct current stimulation over the left prefrontal cortex facilitates cognitive flexibility in tool use. Cogn Neurosci 4:81-9
Chrysikou, Evangelia G; Weber, Matthew J; Thompson-Schill, Sharon L (2013) A matched filter hypothesis for cognitive control. Neuropsychologia :
Nozari, Nazbanou; Thompson-Schill, Sharon L (2013) More attention when speaking: does it help or does it hurt? Neuropsychologia 51:2770-80

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