Aphasia is a stroke-related disability of language processing that affects about one million people in the United States. Human activity is so dependent on spoken communication that impairments of spoken language processing, such as aphasia, can be devastating. In addition to functional impairments such as inability to work, language impairments can also cause social isolation and its consequent negative outcomes on mental and physical health. Because language processing calls on many different cognitive faculties, aphasia may have many different underlying causes and each aphasic individual may have a subtly different impairment. Designing effective rehabilitation strategies depends on our understanding of the nature of the impairment, thus, the focus of this proposal is on using behavioral experiments and computational modeling methods to develop a formal theory of aphasic spoken word comprehension. The proposed experiments will investigate phonological, semantic, and cognitive control aspects of word processing in a large and diverse set of aphasic individuals and unimpaired control participants using behavioral and eye tracking measures. These measures will provide new insights into the dynamics of word processing in aphasia. Computational modeling will be used to develop and test formal accounts of word processing deficits in aphasia. With a better understanding of the underlying causes of aphasic language impairments and a formal model of aphasia, more effective rehabilitation strategies can be developed.

Public Health Relevance

This project will apply innovative behavioral, eye-tracking, and computational modeling techniques to better understand word processing in aphasic patients. The investigations are likely to contribute substantially to the understanding of language impairments in aphasia and to the development of novel rehabilitation strategies for aphasia.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Research Project (R01)
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Study Section
Language and Communication Study Section (LCOM)
Program Officer
Cooper, Judith
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Albert Einstein Medical Center (Philadelphia)
United States
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Lee, Chia-Iin; Mirman, Daniel; Buxbaum, Laurel J (2014) Abnormal dynamics of activation of object use information in apraxia: evidence from eyetracking. Neuropsychologia 59:13-26
Britt, Allison E; Mirman, Daniel; Kornilov, Sergey A et al. (2014) Effect of repetition proportion on language-driven anticipatory eye movements. Acta Psychol (Amst) 145:128-38
Mirman, Daniel; Britt, Allison E (2014) What we talk about when we talk about access deficits. Philos Trans R Soc Lond B Biol Sci 369:20120388
Mirman, Daniel; Graziano, Kristen M (2013) The neural basis of inhibitory effects of semantic and phonological neighbors in spoken word production. J Cogn Neurosci 25:1504-16
Lee, Chia-lin; Middleton, Erica; Mirman, Daniel et al. (2013) Incidental and context-responsive activation of structure- and function-based action features during object identification. J Exp Psychol Hum Percept Perform 39:257-70
Mirman, Daniel; Britt, Allison E; Chen, Qi (2013) Effects of phonological and semantic deficits on facilitative and inhibitory consequences of item repetition in spoken word comprehension. Neuropsychologia 51:1848-56
Kalenine, Solene; Mirman, Daniel; Middleton, Erica L et al. (2012) Temporal dynamics of activation of thematic and functional knowledge during conceptual processing of manipulable artifacts. J Exp Psychol Learn Mem Cogn 38:1274-95
Chen, Qi; Mirman, Daniel (2012) Competition and cooperation among similar representations: toward a unified account of facilitative and inhibitory effects of lexical neighbors. Psychol Rev 119:417-30