The goal of the proposed research is to characterize the location and functional interaction over time of areas of the brain involved in aspects of sentence comprehension. The research is undertaken within a framework that sees comprehension as having multiple information "sources," and as being "interactive" and "situated." This view of sentence comprehension maintains that the propositional meaning of a sentence is, in the final analysis, determined by its syntactic structure and lexical content, and, when comprehension is successful, this meaning is arrived at by a process that assigns syntactic structure (parsing) and combines it with lexical meanings to determine propositional meaning (syntactically-based interpretation, which we will refer to simply as "interpretation"). However, these integrated, central processes are not the only sources of propositional representations that are considered as candidates for the meaning of a sentence. Propositional meanings are also assigned by asyntactic processes such as heuristics that assign agent to a preverbal noun (comprehension has "multiple sources"). These multiple sources yield candidates for the meaning of a sentence on-line, which are eventually eliminated in favor of the syntactically licensed interpretation(s) of a sentence. In addition, parsing and interpretation are affected in an on-line fashion by a variety of types of information such as the frequency of lexical forms and their co-occurrence (comprehension is "interactive"), and by non- linguistic factors such as task conditions (comprehension is "situated"). The proposed research will identify areas of the brain that are involved in aspects of parsing and interpretive operations and their on-line interaction with non-linguistic processes. We will study the two major types of these interactions - those between parsing and interpretation and perceptual and motor processes and those between parsing and interpretation and semantic memory. We will use MR-constrained integrated magnetoencephalography (MEG) and electroelcephalography (EEG) to obtain measures of neural activity that have both fine-grained temporal and spatial resolution, and apply Granger causation analyses (Granger, 1969) to these data to identify patterns of directional causal influence between functionally interpretable ROIs during sentence processing.

Public Health Relevance

The project will advance our understanding of the complex neural activities that occur during sentence comprehension. As such, the findings will provide a basis for better diagnosis of such disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC011032-03
Application #
8277431
Study Section
Language and Communication Study Section (LCOM)
Program Officer
Cooper, Judith
Project Start
2010-06-01
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2014-05-31
Support Year
3
Fiscal Year
2012
Total Cost
$254,862
Indirect Cost
$110,872
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Caplan, David; Waters, Gloria (2013) Memory mechanisms supporting syntactic comprehension. Psychon Bull Rev 20:243-68
Rapp, Brenda; Caplan, David; Edwards, Susan et al. (2013) Neuroimaging in aphasia treatment research: issues of experimental design for relating cognitive to neural changes. Neuroimage 73:200-7
Caplan, David; Gow, David (2012) Effects of tasks on BOLD signal responses to sentence contrasts: Review and commentary. Brain Lang 120:174-86