Multisensory Integration begins at or before the level of primary auditory cortex (A1) and builds over higher stages. In A1 the effect seems to be mainly a non-auditory """"""""modulation"""""""" of the strength of """"""""driving"""""""" auditory inputs, while in higher areas it may increasingly reflect a higher order """"""""integration"""""""" of auditory and non-auditory information. In A1, auditory/non-auditory interactions use neuronal oscillations as instruments of auditory response amplification, while in higher stages, interactions also entail classic excitatory convergence. Throughout, the impact of inputs'salience (bottom-up), and that of top-down attentional control are believed to crucial. These elements - neuronal oscillations, modulatory-driving interactions, top-down control, and the underlying anatomic circuits - are ubiquitous and crucial to brain operation. Investigating them in the context of multisensory interactions affords a unique unambiguous control over the key inputs since they arise from different receptor surfaces. Our BROAD GOAL is to investigate multisensory interaction across levels of the auditory system as a general model for integrative operations in the brain. We combine anatomical analyses with electrophysiological methods indexing laminar profiles of synaptic activity and concomitant action potentials to differentiate """"""""driving"""""""" auditory inputs and non-auditory """"""""modulatory"""""""" inputs arising from various cortical and subcortical sources, and to determine how these input types interact physiologically during attentive discrimination.
SPECIFIC AIM 1 is to characterize the mechanisms and evolution of multisensory representation across processing levels.
SPECIFIC AIM 2 is to determine how cross modal cues that predict sound timing and location help auditory processing.
SPECIFIC AIM 3 is to characterize the fine structure of driving and modulatory circuits in auditory cortex, emphasizing anatomical correlates of processes examined under Aims 1 and 2. Improved understanding of the critical instrumental functions of neuronal oscillations in processing of driving inputs, their manipulation by modulatory inputs, influences of stimulus salience and attention, and the underlying circuitry, will enhance the mechanistic understanding of normal hearing, as well as those underlying disruptions of hearing that contribute to a number of pathological conditions.

Public Health Relevance

Improved mechanistic understanding of the instrumental functions of neuronal oscillations in the processing of driving inputs, their manipulation by modulatory inputs, the underlying circuitry, and the way that attention orchestrates these elements, will enhance our mechanistic understanding of perceptual/cognitive impairment specific to hearing disorders, and in a spectrum of disorders including ADHD, autism and schizophrenia, where defects in normal connectivity, disruptions of neuronal synchrony and attentional impairments are prominent

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC011490-12
Application #
8196888
Study Section
Special Emphasis Panel (ZRG1-IFCN-H (04))
Program Officer
Platt, Christopher
Project Start
2010-12-01
Project End
2015-11-30
Budget Start
2011-12-01
Budget End
2012-11-30
Support Year
12
Fiscal Year
2012
Total Cost
$487,496
Indirect Cost
$123,250
Name
Nathan Kline Institute for Psychiatric Research
Department
Type
DUNS #
167204762
City
Orangeburg
State
NY
Country
United States
Zip Code
10962
Haegens, Saskia; Barczak, Annamaria; Musacchia, Gabriella et al. (2015) Laminar Profile and Physiology of the α Rhythm in Primary Visual, Auditory, and Somatosensory Regions of Neocortex. J Neurosci 35:14341-52
Trongnetrpunya, Amy; Nandi, Bijurika; Kang, Daesung et al. (2015) Assessing Granger Causality in Electrophysiological Data: Removing the Adverse Effects of Common Signals via Bipolar Derivations. Front Syst Neurosci 9:189
Morillon, Benjamin; Hackett, Troy A; Kajikawa, Yoshinao et al. (2015) Predictive motor control of sensory dynamics in auditory active sensing. Curr Opin Neurobiol 31:230-8
Kang, D; Ding, M; Topchiy, I et al. (2015) Theta-rhythmic drive between medial septum and hippocampus in slow-wave sleep and microarousal: a Granger causality analysis. J Neurophysiol 114:2797-803
Morillon, Benjamin; Schroeder, Charles E (2015) Neuronal oscillations as a mechanistic substrate of auditory temporal prediction. Ann N Y Acad Sci 1337:26-31
Kajikawa, Yoshinao; Frey, Stephen; Ross, Deborah et al. (2015) Auditory properties in the parabelt regions of the superior temporal gyrus in the awake macaque monkey: an initial survey. J Neurosci 35:4140-50
Kajikawa, Yoshinao; Schroeder, Charles E (2015) Generation of field potentials and modulation of their dynamics through volume integration of cortical activity. J Neurophysiol 113:339-51
Musacchia, Gabriella; Large, Edward W; Schroeder, Charles E (2014) Thalamocortical mechanisms for integrating musical tone and rhythm. Hear Res 308:50-9
van Atteveldt, Nienke; Murray, Micah M; Thut, Gregor et al. (2014) Multisensory integration: flexible use of general operations. Neuron 81:1240-53
O'Connell, Monica Noelle; Barczak, Annamaria; Schroeder, Charles E et al. (2014) Layer specific sharpening of frequency tuning by selective attention in primary auditory cortex. J Neurosci 34:16496-508

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