Multisensory Integration begins at or before the level of primary auditory cortex (A1) and builds over higher stages. In A1 the effect seems to be mainly a non-auditory "modulation" of the strength of "driving" auditory inputs, while in higher areas it may increasingly reflect a higher order "integration" of auditory and non-auditory information. In A1, auditory/non-auditory interactions use neuronal oscillations as instruments of auditory response amplification, while in higher stages, interactions also entail classic excitatory convergence. Throughout, the impact of inputs'salience (bottom-up), and that of top-down attentional control are believed to crucial. These elements - neuronal oscillations, modulatory-driving interactions, top-down control, and the underlying anatomic circuits - are ubiquitous and crucial to brain operation. Investigating them in the context of multisensory interactions affords a unique unambiguous control over the key inputs since they arise from different receptor surfaces. Our BROAD GOAL is to investigate multisensory interaction across levels of the auditory system as a general model for integrative operations in the brain. We combine anatomical analyses with electrophysiological methods indexing laminar profiles of synaptic activity and concomitant action potentials to differentiate "driving" auditory inputs and non-auditory "modulatory" inputs arising from various cortical and subcortical sources, and to determine how these input types interact physiologically during attentive discrimination.
SPECIFIC AIM 1 is to characterize the mechanisms and evolution of multisensory representation across processing levels.
SPECIFIC AIM 2 is to determine how cross modal cues that predict sound timing and location help auditory processing.
SPECIFIC AIM 3 is to characterize the fine structure of driving and modulatory circuits in auditory cortex, emphasizing anatomical correlates of processes examined under Aims 1 and 2. Improved understanding of the critical instrumental functions of neuronal oscillations in processing of driving inputs, their manipulation by modulatory inputs, influences of stimulus salience and attention, and the underlying circuitry, will enhance the mechanistic understanding of normal hearing, as well as those underlying disruptions of hearing that contribute to a number of pathological conditions.

Public Health Relevance

Improved mechanistic understanding of the instrumental functions of neuronal oscillations in the processing of driving inputs, their manipulation by modulatory inputs, the underlying circuitry, and the way that attention orchestrates these elements, will enhance our mechanistic understanding of perceptual/cognitive impairment specific to hearing disorders, and in a spectrum of disorders including ADHD, autism and schizophrenia, where defects in normal connectivity, disruptions of neuronal synchrony and attentional impairments are prominent

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC011490-13
Application #
8374406
Study Section
Special Emphasis Panel (ZRG1-IFCN-H (04))
Program Officer
Platt, Christopher
Project Start
2010-12-01
Project End
2015-11-30
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
13
Fiscal Year
2013
Total Cost
$463,123
Indirect Cost
$117,088
Name
Nathan Kline Institute for Psychiatric Research
Department
Type
DUNS #
167204762
City
Orangeburg
State
NY
Country
United States
Zip Code
10962
Kajikawa, Yoshinao; Schroeder, Charles E (2015) Generation of field potentials and modulation of their dynamics through volume integration of cortical activity. J Neurophysiol 113:339-51
Hackett, Troy A; de la Mothe, Lisa A; Camalier, Corrie R et al. (2014) Feedforward and feedback projections of caudal belt and parabelt areas of auditory cortex: refining the hierarchical model. Front Neurosci 8:72
Morillon, Benjamin; Schroeder, Charles E; Wyart, Valentin (2014) Motor contributions to the temporal precision of auditory attention. Nat Commun 5:5255
Musacchia, Gabriella; Large, Edward W; Schroeder, Charles E (2014) Thalamocortical mechanisms for integrating musical tone and rhythm. Hear Res 308:50-9
van Atteveldt, Nienke; Murray, Micah M; Thut, Gregor et al. (2014) Multisensory integration: flexible use of general operations. Neuron 81:1240-53
van Atteveldt, Nienke M; Peterson, Bradley S; Schroeder, Charles E (2014) Contextual control of audiovisual integration in low-level sensory cortices. Hum Brain Mapp 35:2394-411
Hackett, Troy A (2011) Information flow in the auditory cortical network. Hear Res 271:133-46
Kajikawa, Yoshinao; Camalier, Corrie R; de la Mothe, Lisa A et al. (2011) Auditory cortical tuning to band-pass noise in primate A1 and CM: a comparison to pure tones. Neurosci Res 70:401-7
O'Connell, Monica N; Falchier, Arnaud; McGinnis, Tammy et al. (2011) Dual mechanism of neuronal ensemble inhibition in primary auditory cortex. Neuron 69:805-17
Kajikawa, Yoshinao; Schroeder, Charles E (2011) How local is the local field potential? Neuron 72:847-58

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