This project investigates the joint consequences of bilingualism and Alzheimer's disease (AD) for language and cognitive processing, with the goals of shaping psycholinguistic models of bilingualism (Aim 1), testing models of cognitive decline in AD (Aim 2), and characterizing unique aspects in the presentation of bilingual AD (Aim 3). Aging Spanish-English bilinguals are rapidly increasing in numbers in the USA, but almost no information is available on the profile of bilinguals with AD. Using three different models of bilingualism and three models of cognitive decline in AD, we derive specific predictions for the pattern of dual-language decline in bilinguals with AD for several domains (single word production and comprehension, verbal fluency, language switching, cross-language intrusion errors, translation recognition, and management of dual-language activation in sentence reading). Assuming that bilinguals cannot "shut a language off", we test the effects of dual-language activation implicitly and explicitly, and examine effects that may be unique to bilinguals with AD (e.g., integrated presentation of language and control deficits, enhanced effects of the option to use either language, reduced cognate and false-friend effects). We hypothesize that AD primarily affects semantic storage in initial stages of the disease and that the dominant language will be more sensitive to such changes. However, we propose that retrieval deficits and language control problems are also present in bilingual AD, and that these deficits will affect the nondominant language with disease progression and in tasks that maximize interference between languages. In each study we consider if the results generalize to early vs. late bilinguals, and unbalanced vs. balanced bilinguals, and the implications of differences across bilingual types. The proposed studies will constrain models of bilingualism and cognitive decline in AD, will reveal the role of control in language processing, and will determine the typical presentation of bilingual AD while also identifying the conditions that allow bilinguals with AD to communicate as fluently as possible.

Public Health Relevance

Elderly Spanish-English bilinguals are rapidly increasing in numbers, and are at increased risk for developing Alzheimer's disease (AD), yet almost nothing is known about the joint consequences of bilingualism and AD for language and cognitive processing. The current proposal proposes to begin characterizing language deficits in bilingual AD. The proposed studies will provide important information about the presentation and progression of language impairments in bilinguals with AD, and more generally will increase our understanding of bilingualism and cognitive decline in AD.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC011492-04
Application #
8577960
Study Section
Language and Communication Study Section (LCOM)
Program Officer
Cooper, Judith
Project Start
2010-12-01
Project End
2015-11-30
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
4
Fiscal Year
2014
Total Cost
$405,276
Indirect Cost
$142,961
Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Gollan, Tamar H; Starr, Jennie; Ferreira, Victor S (2015) More than use it or lose it: the number-of-speakers effect on heritage language proficiency. Psychon Bull Rev 22:147-55
Gollan, Tamar H; Kleinman, Daniel; Wierenga, Christina E (2014) What's easier: doing what you want, or being told what to do? Cued versus voluntary language and task switching. J Exp Psychol Gen 143:2167-95
Ivanova, Iva; Salmon, David P; Gollan, Tamar H (2014) Which language declines more? longitudinal versus cross-sectional decline of picture naming in bilinguals with Alzheimer's disease. J Int Neuropsychol Soc 20:534-46
Wardlow, Liane; Ivanova, Iva; Gollan, Tamar H (2014) The cognitive mechanisms underlying perspective taking between conversational partners: evidence from speakers with Alzheimer?s disease. Neuropsychologia 56:184-95
Gollan, Tamar H; Schotter, Elizabeth R; Gomez, Joanne et al. (2014) Multiple levels of bilingual language control: evidence from language intrusions in reading aloud. Psychol Sci 25:585-95
Gollan, Tamar H; Ferreira, Victor S; Cera, Cynthia et al. (2014) Translation-priming effects on tip-of-the-tongue states. Lang Cogn Process 29:278-288
Wardlow, Liane (2013) Individual differences in speakers' perspective taking: the roles of executive control and working memory. Psychon Bull Rev 20:766-72
Van Assche, Eva; Duyck, Wouter; Gollan, Tamar H (2013) Whole-language and item-specific control in bilingual language production. J Exp Psychol Learn Mem Cogn 39:1781-92
Ivanova, Iva; Salmon, David P; Gollan, Tamar H (2013) The multilingual naming test in Alzheimer's disease: clues to the origin of naming impairments. J Int Neuropsychol Soc 19:272-83
Weissberger, Gali H; Salmon, David P; Bondi, Mark W et al. (2013) Which neuropsychological tests predict progression to Alzheimer's disease in Hispanics? Neuropsychology 27:343-55

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