The overall objective of the proposed experiments is to characterize ultrasonic communication in mice. The mouse is widely used in studies of the auditory system and is thought to be a good model for human communication and audition, yet we know very little about the nature of the mouse's acoustic world. Humans characterizing the vocalizations of mice have been known to place the calls into anywhere from three to six total categories of vocalization types. The proposed studies will avoid human-based categorizations by asking the mouse directly whether they can discriminate or identify calls and whether they have enhanced capabilities for perceptually processing call-like sounds. Ultrasonic vocalizations from juveniles and adults will be recorded and then those same vocalizations will be used in perceptual studies in awake, behaving mice. These studies are urgently needed in the field of audition because so many laboratories regularly use the mouse as a model for hearing and communication in humans and now the differences and commonalities between the two species can be understood and utilized.

Public Health Relevance

The proposed experiments address the importance of studying the awake and behaving mouse when attempting to compare the communication and auditory systems of these animals and humans. Typical categorizations of vocalizations use a statistical or even human-centered 'eyeball'approach, but the current studies will actually ask the animals how they perceive the vocalizations and other sonic and ultrasonic stimuli. The popularity of the mouse model in molecular, physiological, and anatomical studies of the auditory system requires that a more in-depth approach to their auditory system be made, and these experiments propose to do exactly that.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC012302-02
Application #
8580929
Study Section
Auditory System Study Section (AUD)
Program Officer
Donahue, Amy
Project Start
2012-12-01
Project End
2017-11-30
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
2
Fiscal Year
2014
Total Cost
$347,849
Indirect Cost
$122,849
Name
State University of New York at Buffalo
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260
Neilans, Erikson G; Holfoth, David P; Radziwon, Kelly E et al. (2014) Discrimination of ultrasonic vocalizations by CBA/CaJ mice (Mus musculus) is related to spectrotemporal dissimilarity of vocalizations. PLoS One 9:e85405
Radziwon, Kelly E; Dent, Micheal L (2014) Frequency difference limens and auditory cue trading in CBA/CaJ mice (Mus musculus). Behav Processes 106:74-6