The proposed studies will focus on the neural substrates of speech motor development in children. Our plan is to use a multi-modal approach that combines advanced psychophysical and neuroimaging techniques. In our work with adults, in the context of human arm movement, we have developed a powerful new technique to identify changes in brain activity that are specifically related to behavioral measures of learning We have found that changes in brain networks that occur in conjunction with motor learning can be partitioned into those that are primarily motor in nature and those that reflect the perceptual changes that occur in conjunction with motor learning. For the proposed project, we will study healthy children from ages 5 to 12 and healthy adults. We will use fMRI measures of functional connectivity to identify the brain networks that are associated with motor and perceptual changes that occur in association with speech motor learning. We will test the hypothesis that the brain networks associated with speech motor learning can be partitioned, as in limb movement, into those that are primarily associated with the changes in motor function and those involved in the perceptual and sensory aspects of speech motor learning. We propose that the sensory and motor networks active during speech motor learning may function more independently in younger children, becoming more tightly coupled as these systems mature. We will also determine how the brain activity that accompanies speech motor learning is related to the more durable changes in brain networks that are observed under-resting state conditions following training. The hypothesis is that brain activity during speech motor learning involves networks that process sensory errors and those that code predictive or feedforward adjustments associated with adaptation and learning. We will test the idea that patterns of brain activity during task based learning that are related to the these measures can be used to predict durable changes in functional connectivity that are observed after the completion of the learning task.

Public Health Relevance

The goal of the proposed research is to determine the neural substrates of speech motor learning in children and their changes over development. It is striking that almost nothing is presently known about the brain bases of speech motor learning in children. We will use sophisticated experimental models of speech motor learning and have developed experimental techniques to study speech motor learning in children as young as 5 years of age. We have developed brain imaging techniques in the context of human arm movement that we will use here in the proposed research to identify changes to separate networks in the brain that are primarily dependent on motor versus sensory changes that occur in conjunction with speech motor learning. Our work will provide a neurobiological understanding of the brain networks, their organization and the developmental trajectory of speech learning. These are a necessary prerequisite for early diagnosis of speech and language disorders, innovative approaches to treatment and the tracking of important yet subtle therapy-induced changes in brain neuroplasticity.

Agency
National Institute of Health (NIH)
Type
Research Project (R01)
Project #
5R01DC012502-03
Application #
8685939
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Shekim, Lana O
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Haskins Laboratories, Inc.
Department
Type
DUNS #
City
New Haven
State
CT
Country
United States
Zip Code
06511
Lametti, Daniel R; Krol, Sonia A; Shiller, Douglas M et al. (2014) Brief periods of auditory perceptual training can determine the sensory targets of speech motor learning. Psychol Sci 25:1325-36
Lametti, Daniel R; Rochet-Capellan, Amélie; Neufeld, Emily et al. (2014) Plasticity in the human speech motor system drives changes in speech perception. J Neurosci 34:10339-46
Shiller, Douglas M; Rochon, Marie-Lyne (2014) Auditory-perceptual learning improves speech motor adaptation in children. J Exp Psychol Hum Percept Perform 40:1308-15
Mollaei, Fatemeh; Shiller, Douglas M; Gracco, Vincent L (2013) Sensorimotor adaptation of speech in Parkinson's disease. Mov Disord 28:1668-74
Shiller, Douglas M; Bourguignon, Nicolas; Frak, Victor et al. (2013) Word-induced postural changes reflect a tight interaction between motor and lexico-semantic representations. Neurosci Lett 555:129-33