The sense of smell is an early warning system for the detection of environmental hazards such as spoiled food, natural gas leaks, smoke, or airborne pollution. Smells also play an important role in quality of life, imparting the flavor of foods and beverages. The long- term objective of this proposal is to understand the nature of odor coding at the receptor level. Currently, little is known about how changes in the receptor activation pattern alter olfactory perception. In the research proposed here, we use next-generation sequencing techniques, heterologous expression systems, and human psychophysics to understand the links between receptor genotype, receptor function and olfactory perception. Learning the rules for transforming receptor activity into perception will advance our understanding of odor coding.

Public Health Relevance

The inability to smell environmental hazards or foods can affect both health and quality of life. Establishing a link between receptors and ligands will allo for the development of receptor agonists and antagonists to be used in direct therapeutic interventions.

Agency
National Institute of Health (NIH)
Type
Research Project (R01)
Project #
3R01DC013339-02S1
Application #
8870713
Study Section
Somatosensory and Chemosensory Systems Study Section (SCS)
Program Officer
Sullivan, Susan L
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Monell Chemical Senses Center
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Mainland, Joel D; Keller, Andreas; Li, Yun R et al. (2014) The missense of smell: functional variability in the human odorant receptor repertoire. Nat Neurosci 17:114-20
Trimmer, Casey; Snyder, Lindsey L; Mainland, Joel D (2014) High-throughput analysis of mammalian olfactory receptors: measurement of receptor activation via luciferase activity. J Vis Exp :
Mainland, Joel D; Lundström, Johan N; Reisert, Johannes et al. (2014) From molecule to mind: an integrative perspective on odor intensity. Trends Neurosci 37:443-54