Project(title:((((((Mechanisms(of(temporal(selectivity(in(the(anuran(auditory(midbrain.(( ( The(temporal(structure(of(signals(plays(important(roles(in(communication.((The(proposed(projects(aim(to( provide(new(insight(into(how(midbrain(neurons(respond(selectively(to(particular(temporal(features(of( communication(sounds,(specifically(pulse(rate(and(duration.(Experiments(will(investigate(the(role(of( NMDA-type(receptors(in(amplifying(responses(and(augmenting(temporal(selectivity.(((Other(experiments( will(be(the(first(to(explore(the(role(of(projections(from(the(nucleus(of(the(lateral(lemniscus(to(the(inferior( colliculus(in(generating(temporal(selectivity.((Focal(pharmacological(manipulations(will(be(combined(with( whole-cell(intracellular(recordings.((We(also(propose(to(use(new(computational(methodology(to( delineate(the(time(course(of(excitatory(and(inhibitory(conductances.((This(novel(and(powerful( methodological(approach(has(only(recently(been(applied(to(the(in(vivo(study(of(central(auditory(systems( (Rose(et(al.,(2013),(and(holds(great(promise(for(enabling(auditory(system(researchers,(as(well(as(the( neuroscience(community(at(large,(to(gain(unprecedented(insight(into(the(mechanisms(that(underlie( computations(in(the(brain.((This(approach(will(also(be(used(to(investigate(the(roles(of(dynamic( properties(of(inhibition,(and(thereby(evaluate(a(new(model(of(interval(selectivity.((The(last(set(of( experiments(will(investigate(whether(IC(neurons(of(the(various(temporal(selectivity(classes(respond( selectively(to(particular(natural(calls(of(leopard(frogs.((These(new(experiments(are(expected(to(further( our(understanding(of(the(network(and(cellular(properties(that(underlie(the(temporal(selectivity(of( midbrain(neurons.(((
Deficiencies in the neural processing of temporal information figure prominently in disorders of speech recognition. For example, impaired recognition of speech appears to stem, in part, from age-related deficits in temporal interval discrimination. The neural bases of these deficits are still unclear; it is therefore, important to understand how auditory systems encode and process the temporal structure of acoustic signals.