Project(title:((((((Mechanisms(of(temporal(selectivity(in(the(anuran(auditory(midbrain.(( ( The(temporal(structure(of(signals(plays(important(roles(in(communication.((The(proposed(projects(aim(to( provide(new(insight(into(how(midbrain(neurons(respond(selectively(to(particular(temporal(features(of( communication(sounds,(specifically(pulse(rate(and(duration.(Experiments(will(investigate(the(role(of( NMDA-type(receptors(in(amplifying(responses(and(augmenting(temporal(selectivity.(((Other(experiments( will(be(the(first(to(explore(the(role(of(projections(from(the(nucleus(of(the(lateral(lemniscus(to(the(inferior( colliculus(in(generating(temporal(selectivity.((Focal(pharmacological(manipulations(will(be(combined(with( whole-cell(intracellular(recordings.((We(also(propose(to(use(new(computational(methodology(to( delineate(the(time(course(of(excitatory(and(inhibitory(conductances.((This(novel(and(powerful( methodological(approach(has(only(recently(been(applied(to(the(in(vivo(study(of(central(auditory(systems( (Rose(et(al.,(2013),(and(holds(great(promise(for(enabling(auditory(system(researchers,(as(well(as(the( neuroscience(community(at(large,(to(gain(unprecedented(insight(into(the(mechanisms(that(underlie( computations(in(the(brain.((This(approach(will(also(be(used(to(investigate(the(roles(of(dynamic( properties(of(inhibition,(and(thereby(evaluate(a(new(model(of(interval(selectivity.((The(last(set(of( experiments(will(investigate(whether(IC(neurons(of(the(various(temporal(selectivity(classes(respond( selectively(to(particular(natural(calls(of(leopard(frogs.((These(new(experiments(are(expected(to(further( our(understanding(of(the(network(and(cellular(properties(that(underlie(the(temporal(selectivity(of( midbrain(neurons.(((

Public Health Relevance

Deficiencies in the neural processing of temporal information figure prominently in disorders of speech recognition. For example, impaired recognition of speech appears to stem, in part, from age-related deficits in temporal interval discrimination. The neural bases of these deficits are still unclear; it is therefore, important to understand how auditory systems encode and process the temporal structure of acoustic signals.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
1R01DC017466-01
Application #
9640061
Study Section
Auditory System Study Section (AUD)
Program Officer
Poremba, Amy
Project Start
2018-12-01
Project End
2023-11-30
Budget Start
2018-12-01
Budget End
2019-11-30
Support Year
1
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Utah
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112