Intrauterine infection is a major cause of pregnancy complications. Fusobacterium nucleatum (Fn), a gram-negative oral anaerobe, is one of the most prevalent species in intrauterine infection. It has been detected in 10-30% of amniotic fluids (AF) associated with preterm birth (PTB), including both preterm labor with intact membranes and premature preterm rupture of membranes (PPROM). Recently, we found Fn to be associated with stillbirth and early-onset neonatal sepsis in human with similar prevalence.
Intrauterine infection is a major cause of pregnancy complications such as preterm birth and stillbirth. Fusobacterium nucleatum (Fn), a common oral bacterium, is one of the most prevalent species in intrauterine infection. Using a highly integrated and state-of-the-art approach, we will analyze the pathogenesis mechanisms of Fn in intrauterine infection to identify potential targets to treat and prevent intrauterine infection. Results from our study will have profound impact on our understanding of this devastating infectious disease and patient management. Moreover, it will shed novel light on how oral bacteria impact infections and inflammation at extra-oral sites.
|Nie, Shuping; Tian, Baoyu; Wang, Xiaowei et al. (2015) Fusobacterium nucleatum subspecies identification by matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol 53:1399-402|
|Han, Yiping W (2015) Fusobacterium nucleatum: a commensal-turned pathogen. Curr Opin Microbiol 23:141-7|
|Han, Yiping Weng (2014) Commentary: Oral bacteria as drivers for colorectal cancer. J Periodontol 85:1155-7|
|Rubinstein, Mara Roxana; Wang, Xiaowei; Liu, Wendy et al. (2013) Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/?-catenin signaling via its FadA adhesin. Cell Host Microbe 14:195-206|