Intrauterine infection is a major cause of pregnancy complications. Fusobacterium nucleatum (Fn), a gram-negative oral anaerobe, is one of the most prevalent species in intrauterine infection. It has been detected in 10-30% of amniotic fluids (AF) associated with preterm birth (PTB), including both preterm labor with intact membranes and premature preterm rupture of membranes (PPROM). Recently, we found Fn to be associated with stillbirth and early-onset neonatal sepsis in human with similar prevalence.

Public Health Relevance

Intrauterine infection is a major cause of pregnancy complications such as preterm birth and stillbirth. Fusobacterium nucleatum (Fn), a common oral bacterium, is one of the most prevalent species in intrauterine infection. Using a highly integrated and state-of-the-art approach, we will analyze the pathogenesis mechanisms of Fn in intrauterine infection to identify potential targets to treat and prevent intrauterine infection. Results from our study will have profound impact on our understanding of this devastating infectious disease and patient management. Moreover, it will shed novel light on how oral bacteria impact infections and inflammation at extra-oral sites.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
1R01DE023332-01
Application #
8477449
Study Section
Special Emphasis Panel (ZRG1-MOSS-B (02))
Program Officer
Lunsford, Dwayne
Project Start
2013-07-05
Project End
2017-06-30
Budget Start
2013-07-05
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$387,475
Indirect Cost
$137,475
Name
Case Western Reserve University
Department
Dentistry
Type
Schools of Dentistry
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Han, Yiping Weng (2014) Commentary: Oral bacteria as drivers for colorectal cancer. J Periodontol 85:1155-7