Intrauterine infection is a major cause of pregnancy complications. Fusobacterium nucleatum (Fn), a gram-negative oral anaerobe, is one of the most prevalent species in intrauterine infection. It has been detected in 10-30% of amniotic fluids (AF) associated with preterm birth (PTB), including both preterm labor with intact membranes and premature preterm rupture of membranes (PPROM). Recently, we found Fn to be associated with stillbirth and early-onset neonatal sepsis in human with similar prevalence.
Intrauterine infection is a major cause of pregnancy complications such as preterm birth and stillbirth. Fusobacterium nucleatum (Fn), a common oral bacterium, is one of the most prevalent species in intrauterine infection. Using a highly integrated and state-of-the-art approach, we will analyze the pathogenesis mechanisms of Fn in intrauterine infection to identify potential targets to treat and prevent intrauterine infection. Results from our study will have profound impact on our understanding of this devastating infectious disease and patient management. Moreover, it will shed novel light on how oral bacteria impact infections and inflammation at extra-oral sites.
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