Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK020478-14
Application #
3226752
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1978-06-01
Project End
1993-07-31
Budget Start
1993-02-01
Budget End
1993-07-31
Support Year
14
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Wang, Junjie; Kumaran, Sowmini; Zhou, Jieyu et al. (2015) Elucidation of the interaction loci of the human pyruvate dehydrogenase complex E2·E3BP core with pyruvate dehydrogenase kinase 1 and kinase 2 by H/D exchange mass spectrometry and nuclear magnetic resonance. Biochemistry 54:69-82
Patel, Mulchand S; Nemeria, Natalia S; Furey, William et al. (2014) The pyruvate dehydrogenase complexes: structure-based function and regulation. J Biol Chem 289:16615-23
Marin-Valencia, Isaac; Good, Levi B; Ma, Qian et al. (2012) Cortical metabolism in pyruvate dehydrogenase deficiency revealed by ex vivo multiplet (13)C NMR of the adult mouse brain. Neurochem Int 61:1036-43
Choi, Cheol Soo; Ghoshal, Pushpankur; Srinivasan, Malathi et al. (2010) Liver-specific pyruvate dehydrogenase complex deficiency upregulates lipogenesis in adipose tissue and improves peripheral insulin sensitivity. Lipids 45:987-95
Srinivasan, Malathi; Choi, Cheol S; Ghoshal, Pushpankur et al. (2010) ß-Cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab 299:E910-7
Patel, Mulchand S; Korotchkina, Lioubov G; Sidhu, Sukhdeep (2009) Interaction of E1 and E3 components with the core proteins of the human pyruvate dehydrogenase complex. J Mol Catal B Enzym 61:2-6
Sidhu, Sukhdeep; Gangasani, Ashish; Korotchkina, Lioubov G et al. (2008) Tissue-specific pyruvate dehydrogenase complex deficiency causes cardiac hypertrophy and sudden death of weaned male mice. Am J Physiol Heart Circ Physiol 295:H946-H952
Korotchkina, Lioubov G; Patel, Mulchand S (2008) Binding of pyruvate dehydrogenase to the core of the human pyruvate dehydrogenase complex. FEBS Lett 582:468-72
Korotchkina, Lioubov G; Sidhu, Sukhdeep; Patel, Mulchand S (2006) Characterization of testis-specific isoenzyme of human pyruvate dehydrogenase. J Biol Chem 281:9688-96
Patel, M S; Korotchkina, L G (2006) Regulation of the pyruvate dehydrogenase complex. Biochem Soc Trans 34:217-22

Showing the most recent 10 out of 55 publications