Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK025377-16
Application #
2137710
Study Section
Endocrinology Study Section (END)
Project Start
1979-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10029
Orlowski, Marian; Wilk, Sherwin (2003) Ubiquitin-independent proteolytic functions of the proteasome. Arch Biochem Biophys 415:1-5
Orlowski, M (2001) Selective activation of the 20 S proteasome (multicatalytic proteinase complex) by histone h3. Biochemistry 40:15318-26
Lu, X; Michaud, C; Orlowski, M (2001) Heat shock protein-90 and the catalytic activities of the 20 S proteasome (multicatalytic proteinase complex). Arch Biochem Biophys 387:163-71
Orlowski, M; Wilk, S (2000) Catalytic activities of the 20 S proteasome, a multicatalytic proteinase complex. Arch Biochem Biophys 383:16-Jan
Wang, R; Chait, B T; Wolf, I et al. (1999) Lysozyme degradation by the bovine multicatalytic proteinase complex (proteasome): evidence for a nonprocessive mode of degradation. Biochemistry 38:14573-81
Cardozo, C; Michaud, C; Orlowski, M (1999) Components of the bovine pituitary multicatalytic proteinase complex (proteasome) cleaving bonds after hydrophobic residues. Biochemistry 38:9768-77
Anton, L C; Snyder, H L; Bennink, J R et al. (1998) Dissociation of proteasomal degradation of biosynthesized viral proteins from generation of MHC class I-associated antigenic peptides. J Immunol 160:4859-68
Orlowski, R Z; Eswara, J R; Lafond-Walker, A et al. (1998) Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor. Cancer Res 58:4342-8
Cardozo, C; Kohanski, R A (1998) Altered properties of the branched chain amino acid-preferring activity contribute to increased cleavages after branched chain residues by the ""immunoproteasome"". J Biol Chem 273:16764-70
Vinitsky, A; Anton, L C; Snyder, H L et al. (1997) The generation of MHC class I-associated peptides is only partially inhibited by proteasome inhibitors: involvement of nonproteasomal cytosolic proteases in antigen processing? J Immunol 159:554-64

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