Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK032770-12S1
Application #
2138869
Study Section
Biochemistry Study Section (BIO)
Project Start
1983-08-01
Project End
1997-07-31
Budget Start
1994-09-01
Budget End
1995-07-31
Support Year
12
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Li, X; Shambaugh, M E; Rottman, F M et al. (2000) SR proteins Asf/SF2 and 9G8 interact to activate enhancer-dependent intron D splicing of bovine growth hormone pre-mRNA in vitro. RNA 6:1847-58
Dirksen, W P; Li, X; Mayeda, A et al. (2000) Mapping the SF2/ASF binding sites in the bovine growth hormone exonic splicing enhancer. J Biol Chem 275:29170-7
Stallings-Mann, M L; Ludwiczak, R L; Klinger, K W et al. (1996) Alternative splicing of exon 3 of the human growth hormone receptor is the result of an unusual genetic polymorphism. Proc Natl Acad Sci U S A 93:12394-9
Dirksen, W P; Sun, Q; Rottman, F M (1995) Multiple splicing signals control alternative intron retention of bovine growth hormone pre-mRNA. J Biol Chem 270:5346-52
Dirksen, W P; Hampson, R K; Sun, Q et al. (1994) A purine-rich exon sequence enhances alternative splicing of bovine growth hormone pre-mRNA. J Biol Chem 269:6431-6
Sun, Q; Hampson, R K; Rottman, F M (1993) In vitro analysis of bovine growth hormone pre-mRNA alternative splicing. Involvement of exon sequences and trans-acting factor(s). J Biol Chem 268:15659-66
Sun, Q; Mayeda, A; Hampson, R K et al. (1993) General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes Dev 7:2598-608
Salata, R A; Malhotra, I J; Hampson, R K et al. (1992) Application of an immune-tolerizing procedure to generate monoclonal antibodies specific to an alternate protein isoform of bovine growth hormone. Anal Biochem 207:142-9
Goodwin, E C; Rottman, F M (1992) The 3'-flanking sequence of the bovine growth hormone gene contains novel elements required for efficient and accurate polyadenylation. J Biol Chem 267:16330-4
Helms, S R; Rottman, F M (1990) Characterization of an inducible promoter system to investigate decay of stable mRNA molecules. Nucleic Acids Res 18:255-9

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