Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK039957-11S1
Application #
2612855
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1987-07-01
Project End
1999-06-30
Budget Start
1997-07-01
Budget End
1998-06-30
Support Year
11
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Surgery
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Poole, Daniel P; Lieu, TinaMarie; Pelayo, Juan Carlos et al. (2015) Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system. Am J Physiol Gastrointest Liver Physiol 309:G248-59
Pelayo, Juan-Carlos; Veldhuis, Nicholas A; Eriksson, Emily M et al. (2014) Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon. Cell Tissue Res 356:319-32
Alemi, Farzad; Kwon, Edwin; Poole, Daniel P et al. (2013) The TGR5 receptor mediates bile acid-induced itch and analgesia. J Clin Invest 123:1513-30
Cattaruzza, Fiore; Poole, Daniel P; Bunnett, Nigel W (2013) Arresting inflammation: contributions of plasma membrane and endosomal signalling to neuropeptide-driven inflammatory disease. Biochem Soc Trans 41:137-43
Rajagopal, Senthilkumar; Kumar, Divya P; Mahavadi, Sunila et al. (2013) Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway. Am J Physiol Gastrointest Liver Physiol 304:G527-35
Alemi, Farzad; Poole, Daniel P; Chiu, Jonathan et al. (2013) The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice. Gastroenterology 144:145-54
Veldhuis, Nicholas A; Lew, Michael J; Abogadie, Fe C et al. (2012) N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor. J Biol Chem 287:21765-72
Law, Ivy Ka Man; Murphy, Jane E; Bakirtzi, Kyriaki et al. (2012) Neurotensin-induced proinflammatory signaling in human colonocytes is regulated by ?-arrestins and endothelin-converting enzyme-1-dependent endocytosis and resensitization of neurotensin receptor 1. J Biol Chem 287:15066-75
Hasdemir, Burcu; Mahajan, Shilpi; Bunnett, Nigel W et al. (2012) Endothelin-converting enzyme-1 actions determine differential trafficking and signaling of corticotropin-releasing factor receptor 1 at high agonist concentrations. Mol Endocrinol 26:681-95
Murphy, Jane E; Roosterman, Dirk; Cottrell, Graeme S et al. (2011) Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor. Am J Physiol Cell Physiol 301:C780-91

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