Diabetes, particularly non-insulin dependent diabetes mellitus (NIDDM), and its complications have become an increasingly important health problem for many American Indian populations. Data on the progression of NIDDM risk factors from early ages are scarce. This application proposes an epidemiologic study to evaluate a number of potential risk factors for NIDDM among members of the Cherokee Nation of Oklahoma. A stratified sample of subjects will be taken across a wide range of ages and degrees of Indian blood from childhood to adulthood. Some of these risk factors are also related to cardiovascular disease, a major complication of diabetes. The study will use a pseudo-cohort design to evaluate fasting glucose and insulin, glucose tolerance, and a number of potential risk factors for NIDDM (and cardiovascular disease), such as family history of diabetes, degree of Indian blood, obesity, diet, lipids and lipoproteins, physical activity, and social and economic factors, in the Cherokees aged 5 to 40 years. The major objectives are (1) to estimate the prevalence of obesity, impaired glucose tolerance (IGT), and diabetes in Cherokees less than 40 years of age, (2) to estimate the progressive differences in these variables from childhood to adulthood, (3) to determine the relationships between the risk factors and fasting glucose and insulin, and glucose tolerance at different ages and whether the relationships vary with age, (4) to estimate the age ranges in which obesity, elevated fasting glucose, glucose intolerance, insulin resistance, and abnormal lipids and lipoproteins occur, (5) to determine the effect of degree of Indian blood on fasting glucose, insulin, glucose intolerance, and other potential risk factors for NIDDM (and CVD), and (6) based on the information obtained, to recommend educational programs and other timely preventive measures and, consequently, reduce the burden of diabetes and improve the health status of American Indians. A pilot study of 218 participants was completed in 1992 with a planning grant from NIDDK. Through the pilot study, logistics of blood sample collection, transport, assay, and data collection and analysis have been worked out. Estimates of risk factors determined from the results of the pilot study facilitated sample size determination. The Cherokee Nation is selected as the study population because of its high prevalence of diabetes, varying degree of Indian blood, large membership, excellent health care facilities, and strong interest in research among the leaders and health professionals.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK047920-04
Application #
2654527
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Harris, Maureen I
Project Start
1995-02-01
Project End
2000-01-31
Budget Start
1998-03-15
Budget End
1999-01-31
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Oklahoma Health Sciences Center
Department
Type
Schools of Public Health
DUNS #
937727907
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117
Wang, Wenyu; Blackett, Piers; Khan, Sohail et al. (2017) Apolipoproteins A-I, B, and C-III and Obesity in Young Adult Cherokee. J Lipids 2017:8236325
Wang, Wenyu; Khan, Sohail; Blackett, Piers et al. (2013) Apolipoproteins A-I, B, and C-III in young adult Cherokee with metabolic syndrome with or without type 2 diabetes. J Clin Lipidol 7:38-42
Alaupovic, Petar; Blackett, Piers; Wang, Wenyu et al. (2008) Characterization of the metabolic syndrome by apolipoproteins in the Oklahoma Cherokee. J Cardiometab Syndr 3:193-9
Eichner, June E; Cravatt, Kymberly; Beebe, Laura A et al. (2005) Tobacco use among American Indians in Oklahoma: an epidemiologic view. Public Health Rep 120:192-9
Wang, Wenyu; Lee, Elisa T; Alaupovic, Petar et al. (2005) Correlation between lipoprotein(a) and other risk factors for cardiovascular disease and diabetes in Cherokee Indians: the Cherokee Diabetes Study. Ann Epidemiol 15:390-7
Blackett, Piers R; Blevins, Kathleen S; Stoddart, Martha et al. (2005) Body mass index and high-density lipoproteins in Cherokee Indian children and adolescents. Pediatr Res 58:472-7
Blackett, Piers R; Blevins, Kathleen S; Quintana, Elaine et al. (2005) ApoC-III bound to apoB-containing lipoproteins increase with insulin resistance in Cherokee Indian youth. Metabolism 54:180-7
Lee, Elisa T; Begum, Momotaz; Wang, Wenyu et al. (2004) Type 2 diabetes and impaired fasting glucose in American Indians aged 5-40 years: the Cherokee diabetes study. Ann Epidemiol 14:696-704
Jansen, Angela M; Lockatell, C Virginia; Johnson, David E et al. (2003) Visualization of Proteus mirabilis morphotypes in the urinary tract: the elongated swarmer cell is rarely observed in ascending urinary tract infection. Infect Immun 71:3607-13
Dattelbaum, Jonathan D; Lockatell, C Virginia; Johnson, David E et al. (2003) UreR, the transcriptional activator of the Proteus mirabilis urease gene cluster, is required for urease activity and virulence in experimental urinary tract infections. Infect Immun 71:1026-30

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