Funding for this project, Nutritional Etiology of Pre-Diabetic Autoimmunity, began in May 1997 and allowed us to create and follow two unique cohorts of children. The first is a cohort of children who have a known risk for diabetes because they a) had been typed for diabetes-related HLA genotypes through a cord blood screening of over 30,000 general population children or b) are a sibling or offspring of someone with type 1 diabetes. This cohort is followed longitudinally for the development of diabetes-related autoimmunity. The second cohort consists of children who have tested positive for at least one diabetes autoantibody and who are followed over time to determine risk factors for conversion to diabetes. These two cohorts have been identified through the Diabetes Autoimmunity Study in the Young (DAISY) (R01-DK32493). A prospective follow-up of these cohorts has already provided important new information concerning the roles of cereal in the infant diet and in utero exposure to vitamin D on risk of islet autoimmunity, as well as predictors of oxidative stress in healthy children. In this competitive renewal application, we are proposing to extend the follow up of these cohorts in order to continue to address the original specific aims concerning anti-oxidants and oxidative stress, as well as investigate additional research areas that we have proposed based on our preliminary findings, including the roles of gut permeability and cereal grains, obesity and its associated inflammation, and gene-nutrient interactions. New findings from the Nutritional Etiology of Pre-diabetic Autoimmunity study will be valuable to the ongoing investigation of the nutritional causes of type 1 diabetes;and our study will continue to act as a pivotal vanguard project to the dietary studies of The Environmental Determinants of Diabetes in the Young study (TEDDY, U01-DK63821), particularly as our study children pass through the highest risk age group for type 1 diabetes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK049654-14
Application #
8109199
Study Section
Kidney, Nutrition, Obesity and Diabetes (KNOD)
Program Officer
Akolkar, Beena
Project Start
1997-06-20
Project End
2013-07-31
Budget Start
2011-08-01
Budget End
2013-07-31
Support Year
14
Fiscal Year
2011
Total Cost
$591,007
Indirect Cost
Name
University of Colorado Denver
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Frohnert, Brigitte I; Laimighofer, Michael; Krumsiek, Jan et al. (2017) Prediction of type 1 diabetes using a genetic risk model in the Diabetes Autoimmunity Study in the Young. Pediatr Diabetes :
Hall, Katelyn; Frederiksen, Brittni; Rewers, Marian et al. (2015) Daycare attendance, breastfeeding, and the development of type 1 diabetes: the diabetes autoimmunity study in the young. Biomed Res Int 2015:203947
Frederiksen, Brittni N; Seifert, Jennifer; Kroehl, Miranda et al. (2015) Timing of solid food introduction is associated with urinary F2-isoprostane concentrations in childhood. Pediatr Res 78:451-6
Lamb, Molly M; Frederiksen, Brittni; Seifert, Jennifer A et al. (2015) Sugar intake is associated with progression from islet autoimmunity to type 1 diabetes: the Diabetes Autoimmunity Study in the Young. Diabetologia 58:2027-34
Rønningen, Kjersti S; Norris, Jill M; Knip, Mikael (2015) Environmental Trigger(s) of Type 1 Diabetes: Why Is It So Difficult to Identify? Biomed Res Int 2015:847906
Lamb, Molly M; Miller, Melissa; Seifert, Jennifer A et al. (2015) The effect of childhood cow's milk intake and HLA-DR genotype on risk of islet autoimmunity and type 1 diabetes: the Diabetes Autoimmunity Study in the Young. Pediatr Diabetes 16:31-8
Frederiksen, Brittni N; Kroehl, Miranda; BarĂ³n, Anna et al. (2015) Assessing age-related etiologic heterogeneity in the onset of islet autoimmunity. Biomed Res Int 2015:708289
Norris, Jill M; Kroehl, Miranda; Fingerlin, Tasha E et al. (2014) Erythrocyte membrane docosapentaenoic acid levels are associated with islet autoimmunity: the Diabetes Autoimmunity Study in the Young. Diabetologia 57:295-304
Frederiksen, Brittni N; Kroehl, Miranda; Fingerlin, Tasha E et al. (2013) Association between vitamin D metabolism gene polymorphisms and risk of islet autoimmunity and progression to type 1 diabetes: the diabetes autoimmunity study in the young (DAISY). J Clin Endocrinol Metab 98:E1845-51
Frederiksen, Brittni; Kroehl, Miranda; Lamb, Molly M et al. (2013) Infant exposures and development of type 1 diabetes mellitus: The Diabetes Autoimmunity Study in the Young (DAISY). JAMA Pediatr 167:808-15

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