The objective of the proposed research is to identify and resolve molecular mechanisms that coordinate energy balance in mammals. The two focuses of this proposal are a gene specific transcription factor, C/EBPalpha, and one of its targets, the ob gene. The first specific aim will address the question of how mammals selectively express the C/EBPalpha gene in organs that produce, store and mobilize energy. The second specific aim will examine the signaling pathways that regulate the activity of C/EBPalpha and determine how these pathways respond to system-wide hormonal cues.
Specific aims 3 and 4 are directed towards the identification of humoral factors that control expression of the ob gene in mature adipocytes and assignment of cis-acting DNA sequences and transcription factors that facilitate transcriptional regulation of the ob gene in response to such factors.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK052031-05
Application #
6342484
Study Section
Nutrition Study Section (NTN)
Program Officer
Haft, Carol Renfrew
Project Start
1997-01-01
Project End
2001-12-31
Budget Start
2001-01-01
Budget End
2001-12-31
Support Year
5
Fiscal Year
2001
Total Cost
$412,643
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Genetics
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
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