Lupus is a systemic autoimmune disease that is complex in genetics and its immunological origins. Renaldisease is a leading cause of morbidity and mortality in lupus, particularly among minority women.Although serial renal biopsies may be ideal in closely monitoring the progression of lupus nephritis, it maynot be practical or feasible. Hence, the long-term goal of these studies is to identify potential biomarkers thatmay be of use in monitoring the progression of renal disease in lupus.Using different proteomic approaches, we have uncovered several molecules that appear in the urine duringantibody-mediated nephritis. Our completed cross-sectional studies have helped uncover 6 potentialbiomarker candidates in the urine of mice and patients with lupus. In this proposal, we will study a cohort oflupus patients, 90% of whom are minority individuals, in a longitudinal fashion in order to determine if anyof the urinary biomarker candidates might be better at predicting flares, severe histological nephritis, or endstage renal disease, compared to currently used laboratory yardsticks. In addition, we propose to establish thespecificity of these biomarkers for lupus nephritis, as well as other causes of proteinuria and nephritis.Given the high incidence of end stage renal disease in lupus, early diagnosis and prompt treatment isabsolutely essential. Identification of more predictive biomarkers in the urine of these patients could have aprofound impact on the clinical management of lupus nephritis.

Public Health Relevance

Given the high incidence of end stage renal disease in minority women with lupus; earlydiagnosis and prompt treatment is absolutely essential. Identification of surrogatebiomarkers in the urine of these patients could have a profound impact on the clinicalmanagement of lupus nephritis. Finally; establishing the pathogenic roles of some ofthese biomarkers; may pave the way towards better therapy for this disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
7R01DK081872-06
Application #
8787545
Study Section
Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section (HAI)
Program Officer
Flessner, Michael Francis
Project Start
2009-09-01
Project End
2014-08-31
Budget Start
2013-09-03
Budget End
2014-08-31
Support Year
6
Fiscal Year
2013
Total Cost
$418,991
Indirect Cost
$121,237
Name
University of Houston
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
036837920
City
Houston
State
TX
Country
United States
Zip Code
77204
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