Bladder pain syndrome (BPS or interstitial cystitis, IC) patients typically exhibit marked tenderness of pelvic floor musculature and that treatments directed solely at those muscles often resulted in marked improvement of bladder symptoms. This debilitating syndrome of unknown etiology is often postulated, but not proven, to be associated with microbial infection. To better understand the mechanisms that contribute to BPS/IC, we will study an animal model in which pelvic floor muscle injury alone (somatic injury) the degree to which damage- associated molecular patterns (DAMPs) signal through neuronal receptors that recognize pathogen-associated molecular patterns (PAMPs). A potential neurobiological mechanism for the behavioral changes observed with this injury model is the increased nociceptive signaling present in bladder-associated sensory ganglia. To this end, validation of our injury paradigm in the rodent as an experimental representation of BPS/IC provides us with a number of parameters with which to test potential mediators of somatic and visceral hypersensitivity. Furthermore, the outcomes of these proposed experiments may also provide potential therapeutic targets. Taken together, the use of a clinically-relevant animal model will provide us with the unique opportunity to improve PBS/IC diagnostic and treatment paradigms and increase the understanding of the mechanisms underlying the development and maintenance of chronic pelvic pain conditions in women.

Public Health Relevance

There is general agreement that bladder pain syndrome/interstitial cystitis (BPS/IC) is a visceral pain syndrome that also includes symptoms of urinary frequency, urgency and pain related to bladder filling. We will investigate the hypothesis that the nociceptive signaling which may account for the symptoms of pain may be due to the degree to which damage-associated molecular patterns (DAMPs) that signal through neuronal receptors that recognize pathogen-associated molecular patterns. This neuronal signaling may directly influence in the recurring discomfort or pain in the bladder and the surrounding pelvic region.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
1R01DK100905-01
Application #
8627400
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (O2))
Program Officer
Kirkali, Ziya
Project Start
2013-09-27
Project End
2014-09-26
Budget Start
2013-09-27
Budget End
2014-09-26
Support Year
1
Fiscal Year
2013
Total Cost
$390,000
Indirect Cost
$140,000
Name
Indiana University-Purdue University at Indianapolis
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
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Weber, Daniel J; Gracon, Adam S A; Ripsch, Matthew S et al. (2014) The HMGB1-RAGE axis mediates traumatic brain injury-induced pulmonary dysfunction in lung transplantation. Sci Transl Med 6:252ra124