We will determine whether key characteristics of the newly discovered female urinary microbiome, the bacterial community living in the bladder of many adult women, associate strongly with two common forms of urinary incontinence (stress urinary incontinence [SUI] and urgency urinary incontinence [UUI]). To perform this study, Loyola investigators will recruit approximately 1200 women (400 each from two, well- characterized urinary incontinence cohorts and 400 continent controls). They will determine whether certain bacterial species, or entire microbiomes, are related to urinary incontinence symptoms. A significant difference between these clinical subgroups would suggest a relationship between urinary incontinence and the female urinary microbiome (FUM). One FUM member with antibacterial properties will be studied. Our team has diverse expertise including clinicians specializing in urinary incontinence care, and scientists specializing in microbiology and bioinformatics.

Public Health Relevance

This project will play a central clinical-translational role with participant recruitment, sample acquisition and data analysis focused on improving the quality-of-life for women with urinary incontinence.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK104718-03
Application #
9458739
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Bavendam, Tamara G
Project Start
2016-04-01
Project End
2021-03-31
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
3
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Loyola University Chicago
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
791277940
City
Maywood
State
IL
Country
United States
Zip Code
60153
Brubaker, Linda; Wolfe, Alan J (2017) The Female Urinary Microbiota/Microbiome: Clinical and Research Implications. Rambam Maimonides Med J 8:
Brubaker, Linda; Wolfe, Alan J (2017) Microbiota in 2016: Associating infection and incontinence with the female urinary microbiota. Nat Rev Urol 14:72-74
Mueller, Elizabeth R; Wolfe, Alan J; Brubaker, Linda (2017) Female urinary microbiota. Curr Opin Urol 27:282-286
Schwaderer, Andrew L; Wolfe, Alan J (2017) The association between bacteria and urinary stones. Ann Transl Med 5:32
Gao, Xiang; Lin, Huaiying; Dong, Qunfeng (2017) A Dirichlet-Multinomial Bayes Classifier for Disease Diagnosis with Microbial Compositions. mSphere 2:
Thomas-White, Krystal; Brady, Megan; Wolfe, Alan J et al. (2016) The bladder is not sterile: History and current discoveries on the urinary microbiome. Curr Bladder Dysfunct Rep 11:18-24
Brubaker, Linda; Wolfe, Alan (2016) The urinary microbiota: a paradigm shift for bladder disorders? Curr Opin Obstet Gynecol 28:407-12
Thomas-White, Krystal J; Hilt, Evann E; Fok, Cynthia et al. (2016) Incontinence medication response relates to the female urinary microbiota. Int Urogynecol J 27:723-33