Elastography has been under development during the last decade and is recognized as having great potential as an emerging major tool for breast and prostate cancer diagnosis. It may also play an important role in other areas such as monitoring tumor ablation therapy and intravascular plaque classification. Initial clinical trials are under way and there is a great need for temporally stable heterogeneous phantoms to enable vigorous development of elastographic hardware and software. The overall objective of this grant is to develop tissue-mimicking (TM) materials and phantoms with long-term stability of elastic, ultrasonic and MR properties. These materials are to be used for developing and performance testing of elastography (elastic imaging) systems. One type of phantom will be used in calibration, standardization and performance assessment of elastography machines and the various algorithms used to create elastograms. Another type of phantom will be used to assess the accuracy of an instrument (Nanolndentor XP(R)) dedicated to in vitro mm-scale mapping of the Young's modulus for thin slices of normal and abnormal tissue specimens. A third type will consist of anthropomorphic phantoms with precisely known geometries and physical properties. These will be made in order to allow a more realistic challenge to elastographic systems under development; such phantoms will include breast and prostate relative to cancer diagnosis and other organs such as the liver regarding tumor ablation. Long-term stability of newly developed materials and heterogeneous phantoms will be completed by monitoring elastic, ultrasonic and MR properties and internal structural configurations of heterogeneous phantoms. Refined heterogeneous performance phantoms and anthropomorphic phantoms will be developed iteratively with assessments and advice from collaborators who are active researchers in ultrasound and MR elastography.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
1R01EB000459-01
Application #
6557172
Study Section
Diagnostic Imaging Study Section (DMG)
Program Officer
Haller, John W
Project Start
2003-02-01
Project End
2006-01-31
Budget Start
2003-02-01
Budget End
2004-01-31
Support Year
1
Fiscal Year
2003
Total Cost
$295,847
Indirect Cost
Name
University of Wisconsin Madison
Department
Physics
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
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Meadowcroft, Mark D; Connor, James R; Smith, Michael B et al. (2009) MRI and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic mice. J Magn Reson Imaging 29:997-1007
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Madsen, E L; Frank, G R; Hobson, M A et al. (2008) Instrument for determining the complex shear modulus of soft-tissue-like materials from 10 to 300 Hz. Phys Med Biol 53:5313-42
Rao, M; Chen, Q; Shi, H et al. (2007) Normal and shear strain estimation using beam steering on linear-array transducers. Ultrasound Med Biol 33:57-66
Hobson, Maritza A; Kiss, Miklos Z; Varghese, Tomy et al. (2007) In vitro uterine strain imaging: preliminary results. J Ultrasound Med 26:899-908
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Madsen, Ernest L; Hobson, Maritza A; Shi, Hairong et al. (2006) Stability of heterogeneous elastography phantoms made from oil dispersions in aqueous gels. Ultrasound Med Biol 32:261-70
Madsen, Ernest L; Hobson, Maritza A; Frank, Gary R et al. (2006) Anthropomorphic breast phantoms for testing elastography systems. Ultrasound Med Biol 32:857-74

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