The purpose of this program is to provide the gastroenterologist with a diagnostic screening tool which will enable him to rapidly survey the region of Barrett's esophagus (BE) in a patient with this disease, and allow him to determine with high probability and in real-time, regions of dysplasia and carcinoma. It will be able to distinguish between the categories of adenocarcinoma, high-grade dysplasia, low-grade dysplasia, indefinite for dysplasia and non-dysplastic BE. It will be able to perform measurements of the full length of the esophagus in about ten minutes and provide the information in real time. Suspicious areas can then be biopsied and the diagnosis verified. This approach is vastly superior to the present strategies of performing either systematic or random biopsies. Thus it will provide a powerful tool for screening the large population of Barrett's esophagus patients for early precancerous changes. This instrument will be based on the technique of light scattering spectroscopy (LSS), which has been demonstrated in a proof-of-principle study to be able to perform such measurements in the epithelial tissue of five different organs, including BE. The advantages of the proposed technique are that it greatly simplifies the time and labor involved in performing screening and obtaining diagnoses, will cause less patient discomfort, require fewer biopsies, and it can help the pathologist to base his diagnosis on uniform quantitative criteria, making the diagnosis more consistent. Because of these advantages, it should vastly improve the probability of detecting potential malignancies in the early stages, when cures are possible, and it should be highly cost effective. Since tissue is not necessarily removed, it makes possible progression studies. Such studies may determine accurate predicative factors for the outcome of the disease, and thus simplify the decision in the choice of treatment.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB003472-04
Application #
7350188
Study Section
Special Emphasis Panel (ZRG1-DIG-E (50))
Program Officer
Zhang, Yantian
Project Start
2005-03-05
Project End
2010-03-31
Budget Start
2008-02-01
Budget End
2010-03-31
Support Year
4
Fiscal Year
2008
Total Cost
$413,322
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02215
Turzhitsky, Vladimir; Zhang, Lei; Horowitz, Gary L et al. (2018) Picoanalysis of Drugs in Biofluids with Quantitative Label-Free Surface-Enhanced Raman Spectroscopy. Small 14:e1802392
Zhang, Lei; Pleskow, Douglas K; Turzhitsky, Vladimir et al. (2017) Light scattering spectroscopy identifies the malignant potential of pancreatic cysts during endoscopy. Nat Biomed Eng 1:
Melo, Sonia A; Sugimoto, Hikaru; O'Connell, Joyce T et al. (2014) Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis. Cancer Cell 26:707-21
Qiu, Le; Turzhitsky, Vladimir; Chuttani, Ram et al. (2012) Spectral Imaging with Scattered Light: From Early Cancer Detection to Cell Biology. IEEE J Sel Top Quantum Electron 18:1073-1083
Vitkin, Edward; Turzhitsky, Vladimir; Qiu, Le et al. (2011) Photon diffusion near the point-of-entry in anisotropically scattering turbid media. Nat Commun 2:587
Qiu, Le; Larson, Timothy A; Vitkin, Edward et al. (2010) Gold nanorod light scattering labels for biomedical imaging. Biomed Opt Express 1:135-142
Qiu, Le; Pleskow, Douglas K; Chuttani, Ram et al. (2010) Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett's esophagus. Nat Med 16:603-6, 1p following 606
Qiu, Le; Chuttani, Ram; Zhang, Songhua et al. (2009) Diagnostic imaging of esophageal epithelium with clinical endoscopic polarized scanning spectroscopy instrument. Conf Proc IEEE Eng Med Biol Soc 2009:1997-2000
Perelman, Lev T (2006) Optical diagnostic technology based on light scattering spectroscopy for early cancer detection. Expert Rev Med Devices 3:787-803