This proposal describes our plans to build a set of software tools and an online capability for generating high-resolution, study-specific atlases from the ADNI database of images and patient data. The proposed tools will rely on the technology for large deformation diffeomorphic metric mappings (LDDMMs), to generate high-quality, multimodal brain atlases. The goal of this project is not merely a single atlas nor is it simply a set of new algorithms. Rather, we will provide an online service through which users can request custom atlases that they specify through a web interface. A computational infrastructure will deliver these atlases to the user. ? ? We will also pursue fundamental and technological improvements in the atlas construction framework as well as the validation of these technologies. In order to provide a clinical context for these developments, we will use these tools to conduct an atlas-based study on metabolic asymmetry in dementia with coinvestigators in the Department of Neurology at the University of Utah. ? ?
The goals of this project are multifold. We will be developing open-source software for generating LDDMMs and a web interface open to researchers around the world for automatically generating and delivering high-quality, on-demand atlases from ADNI database queries. The proposed Brain Atlas Portal will produce, as specified by the user: (i) multimodal imagery, with transformations between subjects and the mean, (ii) reliability index for the atlas, (iii) quantification of structural and metabolic variability of the cohort, and (iv) a set of longitudinal multimodal atlases for a cohort. ? ? ?
| Zhang, Miaomiao; Fletcher, P Thomas (2015) Finite-Dimensional Lie Algebras for Fast Diffeomorphic Image Registration. Inf Process Med Imaging 24:249-59 |
| Zhang, Miaomiao; Fletcher, P Thomas (2015) Bayesian principal geodesic analysis for estimating intrinsic diffeomorphic image variability. Med Image Anal 25:37-44 |
| Yu, Yen-Yun; Fletcher, P Thomas; Awate, Suyash P (2014) Hierarchical bayesian modeling, estimation, and sampling for multigroup shape analysis. Med Image Comput Comput Assist Interv 17:9-16 |
| Awate, Suyash P; Whitaker, Ross T (2014) Multiatlas segmentation as nonparametric regression. IEEE Trans Med Imaging 33:1803-17 |
| Singh, Nikhil; Fletcher, P Thomas; Preston, J Samuel et al. (2014) Quantifying anatomical shape variations in neurological disorders. Med Image Anal 18:616-33 |
| Durrleman, Stanley; Prastawa, Marcel; Charon, Nicolas et al. (2014) Morphometry of anatomical shape complexes with dense deformations and sparse parameters. Neuroimage 101:35-49 |
| Zhang, Miaomiao; Fletcher, P Thomas (2014) Bayesian principal geodesic analysis in diffeomorphic image registration. Med Image Comput Comput Assist Interv 17:121-8 |
| Fogal, Thomas; Proch, Fabian; Schiewe, Alexander et al. (2014) Freeprocessing: Transparent in situ visualization via data interception. Eurographics Symp Parallel Graph Vis 2014:49-56 |
| Fogal, Thomas; Schiewe, Alexander; Krüger, Jens (2013) An Analysis of Scalable GPU-Based Ray-Guided Volume Rendering. Proc IEEE Symp Large Scale Data Anal Vis 2013:43-51 |
| Butson, Christopher R; Tamm, Georg; Jain, Sanket et al. (2013) Evaluation of Interactive Visualization on Mobile Computing Platforms for Selection of Deep Brain Stimulation Parameters. IEEE Trans Vis Comput Graph 19:108-17 |
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