Low gamma nuclei (e.g. 31P, 13C &23Na) MRI/MRSI offers an unmatched imaging modality in studying metabolism and physiology of the human system. Unfortunately, due to the low natural abundance of low gamma nuclei, this promising technique suffers from the low SNR and long acquisition time. Recent breakthroughs in hyperpolarized 13C methods have demonstrated an unprecedented ~50,000-fold SNR gain in-vivo, which provides a great new opportunity for MR metabolic imaging. However its fast signal decay (~1 minute) is a challenge for applying this revolutionary technique to in-vivo applications. With the proven advantages of the intrinsically high sensitivity and fast acquisition, high-field parallel imaging would be a solution to alleviate SNR and long acquisition-time problems. However, implementation of the high-field parallel imaging to low-gamma nuclei in human is hindered by design difficulties for the required multichannel double- tuned transceiver arrays due to the interaction between the different nuclei channels, degraded Q factors, increased """"""""cable-resonance"""""""" and interference of two fields with different frequencies, besides the challenges in a single-tuned proton transceiver array, such as the radiation losses and decoupling difficulties. In fact, the lack of the transceiver arrays has become a major hindrance for low-gamma nuclear high-field parallel MRI/MRSI, and there is a pressing demand for developing robust techniques for design techniques to facilitate the low- gamma nuclei detection, especially for hyperpolarized 13C, using high-field parallel MR imaging in human. Therefore, we propose a comprehensive project for developing multichannel double-tuned transceiver arrays based mainly on the recently developed common-mode and differential mode (CMDM) method with the microstrip transmission (MTL) technique. The major goals of this project are focused on 1) development of general design techniques through proposed array projects with immediate in-vivo applications at UCSF, 2) establishment of theoretical and numerical models to understand and simulate the multichannel double-tuned transceiver arrays in decoupling, dual-frequency interaction, EM fields, resonant frequencies, and SAR, and 3) validations of proposed transceiver array technology with performance comparison, safety assessment and real patient demonstration. The proposed double-tuned transceiver array techniques provides unmatched advantages of high sensitivity, improved isolation between two frequencies, sufficient decoupling, capability of dense-spaced array design, improved Q-factors, and easy construction. This research will provide a robust solution to design of multichannel double-tuned transceiver array for low-gamma nuclear high-field parallel imaging and result in significant technological advances in multinuclear transceiver array engineering. These developments will be critical to the future success of low-gamma nuclear high-field parallel imaging for metabolic and physiological investigations in preclinical and human studies.

Public Health Relevance

The successful outcome of the proposed project will advance the low-gamma nuclear MRI/MRSI with high sensitivity and speed for studying metabolism and physiology in health and diseased conditions in human non- invasively, and make the low-gamma nuclear, in particular, hyperpolarized 13C, MRI/MRSI clinically practical. The research effort will have an immediately impact to better understanding of human physiology, pathology, metabolism and diseases, at molecular level possibly.

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Research Project (R01)
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Biomedical Imaging Technology Study Section (BMIT)
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Liu, Guoying
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University of California San Francisco
Schools of Medicine
San Francisco
United States
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Yan, Xinqiang; Zhang, Xiaoliang; Xue, Rong et al. (2016) Optimizing the ICE decoupling element distance to improve monopole antenna arrays for 7 Tesla MRI. Magn Reson Imaging 34:1264-1268
Rutledge, Omar; Kwak, Tiffany; Cao, Peng et al. (2016) Design and test of a double-nuclear RF coil for (1)H MRI and (13)C MRSI at 7T. J Magn Reson 267:15-21
Yan, Xinqiang; Cao, Zhipeng; Zhang, Xiaoliang (2016) Simulation verification of SNR and parallel imaging improvements by ICE-decoupled loop array in MRI. Appl Magn Reson 47:395-403
Yan, Xinqiang; Pedersen, Jan Ole; Wei, Long et al. (2015) Multichannel Double-Row Transmission Line Array for Human MR Imaging at Ultrahigh Fields. IEEE Trans Biomed Eng 62:1652-9
Yan, Xinqiang; Wei, Long; Xue, Rong et al. (2015) Hybrid monopole/loop coil array for human head MR imaging at 7T. Appl Magn Reson 46:541-550
Yan, Xinqiang; Zhang, Xiaoliang (2015) Decoupling and matching network for monopole antenna arrays in ultrahigh field MRI. Quant Imaging Med Surg 5:546-51
Yan, Xinqiang; Xue, Rong; Zhang, Xiaoliang (2015) Closely-spaced double-row microstrip RF arrays for parallel MR imaging at ultrahigh fields. Appl Magn Reson 46:1239-1248
Milshteyn, Eugene; Zhang, Xiaoliang (2015) The Need and Initial Practice of Parallel Imaging and Compressed Sensing in Hyperpolarized (13)C MRI in vivo. OMICS J Radiol 4:
Cao, Peng; Zhang, Xiaoliang; Park, Ilwoo et al. (2015) (1) H-(13) C independently tuned radiofrequency surface coil applied for in vivo hyperpolarized MRI. Magn Reson Med :
Pang, Yong; Yu, Baiying; Vigneron, Daniel B et al. (2014) Quadrature transmit array design using single-feed circularly polarized patch antenna for parallel transmission in MR imaging. Quant Imaging Med Surg 4:11-8

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