Our primary research interest is in the area of motor neuroprosthetics. We seek to restore function to those suffering from neuromuscular disease and/or paralysis. This study will design and test a novel implantable, epidural micro-electrocorticographic (uECoG) array capable of recording high gamma band activity from the brain for long periods of time (years). We have developed a novel behavioral paradigm in a non-human primate virtual reality simulator to test and optimize the uECoG design. This neuroprosthetic research project will develop the knowledge, tools, and equipment needed to enable paralyzed individuals to control a computer cursor, wheelchair or robotic limb.
The specific aims of this project are to 1) Develop and bench-test 5ECoG electrode array and implantable device platform;2) Determine the optimal electrode diameters and inter-electrode spacings for both open-loop and closed-loop chronic recordings of gamma band activity over motor cortical regions in the non-human primate brain using an epidural 5ECoG electrode;and 3) Determine the optimal epidural 5ECoG signal parameters (i.e. center frequency and bandwidth) and motor cortical region (M1, Pmv, Pmd) for closed-loop BCI control of a computer cursor.
This project will design and test a novel, implantable, thin-film, epidural micro-electrocorticographic electrode array that will allow long-term chronic recording of brain activity. This new electrode design will be optimized for use in a brain-computer interface system that will allow paralyzed individuals to accurately control a computer mouse via direct brain control.
|Dodd, Keith C; Nair, Veena A; Prabhakaran, Vivek (2017) Role of the Contralesional vs. Ipsilesional Hemisphere in Stroke Recovery. Front Hum Neurosci 11:469|
|Krakova, Yelena; Tajalli, Hadi; Thongpang, Sanitta et al. (2014) Spatial differences in corneal electroretinogram potentials measured in rat with a contact lens electrode array. Doc Ophthalmol 129:151-66|
|Lycke, Roy J; Schendel, Amelia; Williams, Justin C et al. (2014) In vivo evaluation of a ?ECoG array for chronic stimulation. Conf Proc IEEE Eng Med Biol Soc 2014:1294-7|
|Schendel, Amelia A; Nonte, Michael W; Vokoun, Corinne et al. (2014) The effect of micro-ECoG substrate footprint on the meningeal tissue response. J Neural Eng 11:046011|
|Park, Dong-Wook; Schendel, Amelia A; Mikael, Solomon et al. (2014) Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications. Nat Commun 5:5258|
|Young, Brittany M; Williams, Justin; Prabhakaran, Vivek (2014) BCI-FES: could a new rehabilitation device hold fresh promise for stroke patients? Expert Rev Med Devices 11:537-9|
|Schendel, Amelia A; Eliceiri, Kevin W; Williams, Justin C (2014) Advanced Materials for Neural Surface Electrodes. Curr Opin Solid State Mater Sci 18:301-307|
|Collinger, Jennifer L; Vinjamuri, Ramana; Degenhart, Alan D et al. (2014) Motor-related brain activity during action observation: a neural substrate for electrocorticographic brain-computer interfaces after spinal cord injury. Front Integr Neurosci 8:17|
|Richner, Thomas J; Thongpang, Sanitta; Brodnick, Sarah K et al. (2014) Optogenetic micro-electrocorticography for modulating and localizing cerebral cortex activity. J Neural Eng 11:016010|
|Wang, Wei; Collinger, Jennifer L; Degenhart, Alan D et al. (2013) An electrocorticographic brain interface in an individual with tetraplegia. PLoS One 8:e55344|
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