The prognosis of pancreatobiliary malignancies with biliary obstructions is generally dismal because of unresectability at the time of presentation and poor response to chemotherapy and radiotherapy. Intrabiliary stenting is currently the best option for the treatment of most malignant biliary obstructions. However, the short term durability of biliary stents necessitates repeated interventions and longer hospital stays with associated high economic burden. In addition, current techniques for systemic chemotherapy do not permit delivery of doses sufficient for effective response at the target sites without substantial undesired toxicities to other organ systems. In the present project, we aim to overcome these problems with currently available medical and surgical treatments of malignant common bile duct (CBD) obstructions. Based on our previous extensive experience with a novel intraluminal MR imaging (MRI)/radiofrequency heating (RFH) prototype system, we are going to establish a new interventional technique. This innovative approach involves (a) intrabiliary MRI-guided local delivery of high-dose chemotherapeutic agents into the CBD wall and adjacent tissues;and (b) intrabiliary MRI-guided, RFH-enhanced local chemotherapy of malignant CBD obstructions. To achieve this goal, we propose three milestones: (i) optimization of the new intrabiliary MRI/RFH prototype system;(ii) preclinical validation of the feasibility of using the new technology to guide and enhance chemotherapeutic drug delivery into the CBD wall and adjacent tissues;and (iii) translation of this novel technology to clinical practice to treat the patients with malignant biliary obstructions. We are convinced that the success of this project could lead to significant breakthroughs in the management of malignant biliary diseases using MRI/RFH-interactive interventional oncologic techniques. Further expansion of this new technology should pave the road to advances in other areas of clinical translational research, including heat-enhanced gene therapy, temperature-sensitive therapies using targeted nanoparticles and peptides, photodynamic therapy, and radiation therapy. Finally, the success of this project should lay the groundwork for development of new technologies to treat obstructive diseases in other luminal systems such as the urinary tract and gastrointestinal tract.
The prognosis of pancreatobiliary malignancies with biliary obstructions is very poor because of unresectability at the time of presentation and poor response to chemotherapy and radiotherapy. We aim to overcome these problems by establishment of a new interventional technique, named Intrabiliary MRI-guided/radiofrequency heat- enhanced local chemotherapy. The success of this project could lead to significant breakthroughs in the management of malignant biliary disease using MR/RF-interactive interventional oncologic techniques.
|Chen, Lumin; Sun, Jihong; Yang, Xiaoming (2016) Radiofrequency ablation-combined multimodel therapies for hepatocellular carcinoma: Current status. Cancer Lett 370:78-84|
|Li, Yangyang; Zhou, Yurong; Li, Xiang et al. (2016) A Facile Approach to Upconversion Crystalline CaF2:Yb(3+),Tm(3+)@mSiO2 Nanospheres for Tumor Therapy. RSC Adv 6:38365-38370|
|Zhang, Feng; Bai, Zhibin; Shi, Yaoping et al. (2015) Interventional MRI-guided local delivery of agents into swine bile duct walls using MR-compatible needle-integrated balloon catheter system. NMR Biomed 28:679-84|
|Luo, Jingfeng; Luo, Yuxuan; Sun, Jihong et al. (2015) Adeno-associated virus-mediated cancer gene therapy: current status. Cancer Lett 356:347-56|
|Wu, Xia; Zhang, Feng; Chen, Ran et al. (2014) Recent advances in imaging-guided interventions for prostate cancers. Cancer Lett 349:114-9|
|Zhang, Feng; Le, Thomas; Wu, Xia et al. (2014) Intrabiliary RF heat-enhanced local chemotherapy of a cholangiocarcinoma cell line: monitoring with dual-modality imaging--preclinical study. Radiology 270:400-8|
|Zhang, Tong; Zhang, Feng; Meng, Yanfeng et al. (2013) Diffusion-weighted MRI monitoring of pancreatic cancer response to radiofrequency heat-enhanced intratumor chemotherapy. NMR Biomed 26:1762-7|
|Meng, Yanfeng; Wang, Jinnan; Sun, Jihong et al. (2013) 3.0-T MR imaging of intracoronary local delivery of motexafin gadolinium into coronary artery walls. Radiology 268:556-62|
|Wang, Han; Zheng, Lin-Feng; Feng, Yan et al. (2012) CTA combined with CT perfusion for assessing the efficacy of anti-angiogenic therapy in rabbit VX2 tumors. Acad Radiol 19:358-65|