Existing studies suggest that tissue elasticity is possibly correlated with the aggressiveness of cancers. Based on results from deformable image registration, the proposed project investigates the possibility of tracking the organs movement subject to external forces and geometric constraints, thereby deducing patient-specific tissue elasticity parameters for proactive health monitoring. The objectives of this exploratory research project are (1) to develop a computational framework based on extensive studies of a large cohort of cancer patients, in order to accurately estimate patent-specific tissu elasticity using a coupled biomechanical simulation-optimization framework on a pair of medical images (possibly from ultrasound, mammography, computed tomography scan, magnetic resonance imaging, or other imaging technologies);(2) to examine potential association between tissue elasticity in different regions with aggressiveness of know/diagnosed cancer in the corresponding regions;(3) to derive predictive models for cancer staging/grading based on recovered patient-specific tissue elasticity and other explanatory variables;(4) to design a health monitoring system based on individualized analysis of tissue elasticity for 'at-risk'groups who are more likely to develop cancers. This proposal describes a truly ambitious effort and a bold vision that is built upon the investigators'prior scientific accomplishments and strong credentials to potentially transform existing practice to more proactive, preventive, evidence-based health monitoring for individuals at risk of developing cancers. This research is expected to make several major scientific advances. These include new algorithms for non-invasive, image-based techniques for automatic extraction of tissue elasticity parameters without force applications and/or force sensing devices, novel regression models and inference procedures for survival analysis, new force sensing devices, novel regression models and inference procedures for survival analysis, new predictive models for cancer staging and grading based on patient-specific tissue elasticity parameters, and a health monitoring system for at-risk groups based on individual tissue elasticity along with other variables.

Public Health Relevance

Other than health monitoring, the patient-specific tissue parameters can be incorporated into medical simulators to perform patient-specific surgical planning, compute desired force-feedback for tele-surgery, design and prototype medical devices, and conduct virtual surgical training. The statistical inference techniques developed can be applicable to genetic epidemiology, health economics, and bioinformatics.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
1R01EB020426-01
Application #
8788148
Study Section
Special Emphasis Panel (ZRG1-HDM-R (60))
Program Officer
Peng, Grace
Project Start
2014-09-30
Project End
2017-05-31
Budget Start
2014-09-30
Budget End
2015-05-31
Support Year
1
Fiscal Year
2014
Total Cost
$223,808
Indirect Cost
$71,120
Name
University of North Carolina Chapel Hill
Department
Biostatistics & Other Math Sci
Type
Schools of Arts and Sciences
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599