Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
7R01ES002852-10
Application #
3250103
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1983-08-01
Project End
1996-11-30
Budget Start
1993-08-01
Budget End
1993-11-30
Support Year
10
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Oklahoma Health Sciences Center
Department
Type
Schools of Pharmacy
DUNS #
937727907
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117
Liu, Y; Fechter, L D (1997) Toluene disrupts outer hair cell morphometry and intracellular calcium homeostasis in cochlear cells of guinea pigs. Toxicol Appl Pharmacol 142:270-7
Liu, Y; Rao, D; Fechter, L D (1997) Correspondence between middle frequency auditory loss in vivo and outer hair cell shortening in vitro. Hear Res 112:134-40
Fechter, L D; Liu, Y; Pearce, T A (1997) Cochlear protection from carbon monoxide exposure by free radical blockers in the guinea pig. Toxicol Appl Pharmacol 142:47-55
Liu, Y; Fechter, L D (1996) Comparison of the effects of trimethyltin on the intracellular calcium levels in spiral ganglion cells and outer hair cells. Acta Otolaryngol 116:417-21
Liu, Y; Fechter, L D (1995) Trimethyltin disrupts loudness recruitment and auditory threshold sensitivity in guinea pigs. Neurotoxicol Teratol 17:281-7
Fechter, L D; Liu, Y (1995) Elevation of intracellular calcium levels in spiral ganglion cells by trimethyltin. Hear Res 91:101-9
Liu, Y; Fechter, L D (1995) MK-801 protects against carbon monoxide-induced hearing loss. Toxicol Appl Pharmacol 132:196-202
Fechter, L D; Liu, Y (1994) Trimethyltin disrupts N1 sensitivity, but has limited effects on the summating potential and cochlear microphonic. Hear Res 78:189-96
Fechter, L D (1993) Effects of acute styrene and simultaneous noise exposure on auditory function in the guinea pig. Neurotoxicol Teratol 15:151-5
Clerici, W J; Chertoff, M E; Brownell, W E et al. (1993) In vitro organotin administration alters guinea pig cochlear outer hair cell shape and viability. Toxicol Appl Pharmacol 120:193-202

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